Decorin: a possible marker for fetal growth restriction

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dc.contributor.authorÇağlar, Mete
dc.contributor.authorYavuzcan, Ali
dc.contributor.authorGöksu, Mehmet
dc.contributor.authorBülbül, Gül Alkan
dc.contributor.authorİsenlik, Bekir Sıtkı
dc.contributor.authorÜstün, Yusuf
dc.contributor.authorKumru, Selahattin
dc.date.accessioned2020-05-01T09:11:17Z
dc.date.available2020-05-01T09:11:17Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionKUMRU, Selahattin/0000-0001-6615-7666en_US
dc.descriptionWOS: 000330586000013en_US
dc.descriptionPubMed: 24256371en_US
dc.description.abstractThe aim of this study was to compare decorin (DCN) levels between pregnancies complicated by idiopathic fetal growth restriction (FGR) and uncomplicated pregnancies and to determine the relationship between DCN levels and clinical parameters. The study population consisted of two groups: control group consisted of 13 women with uncomplicated singleton pregnancies in the third trimester. Study group consisted of 14 singleton pregnancies complicated by idiopathic FGR who were admitted to the hospital for delivery in the third trimester of pregnancy. Maternal and fetal DCN levels were measured. Color Doppler flow assessments were performed. Relationship between DCN levels and clinical parameters was determined. Maternal DCN serum levels were significantly higher in complicated pregnancies by idiopathic FGR (p = 0.01). A statistically significant negative correlation was observed between maternal DCN serum levels and neonatal birth weight (r = -0.0506; p = 0.007). There was a significant correlation between umbilical artery (UA) DCN levels and UA S/D ratio (r = 0.512; p = 0.006) and UA RI (r = 0.405; p = 0.036). The risk of high DCN maternal serum levels (>7986.6 pg/mL) in pregnancy complicated by FGR was 8.25 times higher (RR = 8.25; 95% CI, 1.4-46.8). The results of our study showed that the presence of increased DCN levels in women with FGR could contribute to pathogenesis of the disease.en_US
dc.identifier.doi10.3109/09513590.2013.860125en_US
dc.identifier.endpage144en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage141en_US
dc.identifier.urihttps://doi.org/10.3109/09513590.2013.860125
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5461
dc.identifier.volume30en_US
dc.identifier.wosWOS:000330586000013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiogenesisen_US
dc.subjectdecorinen_US
dc.subjectDoppler velocimetryen_US
dc.subjectidiopathic fetal growth restrictionen_US
dc.titleDecorin: a possible marker for fetal growth restrictionen_US
dc.typeArticleen_US

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