Assessment of myocardial performance index in hypertensive patients with or without hyperuricaemia

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dc.contributor.authorBaşar, Cengiz
dc.contributor.authorBeşli, Feyzullah
dc.contributor.authorÖzhan, Hakan
dc.contributor.authorTürker, Yasin
dc.contributor.authorKayapınar, Osman
dc.contributor.authorKeçebaş, Mesut
dc.date.accessioned2020-04-30T22:39:47Z
dc.date.available2020-04-30T22:39:47Z
dc.date.issued2016
dc.departmentDÜ, Ziraat Fakültesi, Tarla Bitkileri Bölümüen_US
dc.descriptionWOS: 000390164900004en_US
dc.descriptionPubMed: 27160174en_US
dc.description.abstractBackground: Myocardial performance index (MPI) is impaired in patients with hypertension. Uric acid is biologically active and can stimulate oxidative stress, endothelial dysfunction, inflammation, and vasoconstriction. Hyperuricaemia may provide a negative contribution to impaired MPI in hypertension. Aim: The study was designed to assess the MPI in hypertensive patients with or without hyperuricaemia. Methods: A total of 96 consecutive hypertensive patients were divided into two groups according to levels of serum uric acid (SUA); 49 normouricaemic patients (defined as SUA < 7.0 mg/dL in men and < 6.0 mg/dL in women) and 47 hyperuricaemic patients. SUA levels and other biochemistry parameters were determined by a standard analytical technique. All patients were evaluated by two-dimensional and Doppler echocardiography. Results: The two groups were similar according to age, body mass index, and smoking status. Mean MPI value (0.498 +/- 0.06 vs. 0.410 +/- 0.05, p < 0.001) was significantly higher in the hyperuricaemic group than the normouricaemic individuals and positively correlated with the mean value of SUA levels (r = 0.51, p < 0.001). Conclusions: Our study demonstrated that high SUA levels were significantly associated with impaired MPI in hypertensive patients. SUA may suggest a valuable laboratory finding in assessing the risk of developing subclinical impaired left ventricular global function.en_US
dc.identifier.doi10.5603/KP.a2016.0061en_US
dc.identifier.endpage1345en_US
dc.identifier.issn0022-9032
dc.identifier.issn1897-4279
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1339en_US
dc.identifier.urihttps://doi.org/10.5603/KP.a2016.0061
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2825
dc.identifier.volume74en_US
dc.identifier.wosWOS:000390164900004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofKardiologia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthypertensionen_US
dc.subjectserum uric aciden_US
dc.subjectmyocardial performance indexen_US
dc.titleAssessment of myocardial performance index in hypertensive patients with or without hyperuricaemiaen_US
dc.typeArticleen_US

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