Phenotypic features of chronic migraine

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dc.contributor.authorYalın, Osman Özgür
dc.contributor.authorUludüz, Derya
dc.contributor.authorÖzge, Aynur
dc.contributor.authorSungur, Mehmet Ali
dc.contributor.authorSelekler, Macit
dc.contributor.authorSiva, Aksel
dc.date.accessioned2020-04-30T23:20:54Z
dc.date.available2020-04-30T23:20:54Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionSiva, Aksel/0000-0002-8340-6641en_US
dc.descriptionWOS: 000372540100002en_US
dc.descriptionPubMed: 26975363en_US
dc.description.abstractBackground: Chronic migraine is a disabling, under-recognized, and undertreated disorder that increases health burdens. The aim of this study was to evaluate phenotypic features and the relevance of accompanying symptoms of migraine attacks in chronic migraine. Method: This study was conducted as part of an ongoing Turkish Headache Database Study investigating the clinical characteristics and outcomes of headache syndromes in the Turkish population. The electronic database was examined retrospectively, and 835 patients with chronic migraine were included. Results: Patient group consisted of 710 women and 125 men (85 and 15 %, respectively). Mean patient age was 36.8 +/- 13.5 years, median value of migraine onset was 60 months (18-120), median headache frequency was 25 days per month (16-30), median of attack duration was 12 h (4-24), and median of intensity was eight (7-9). Increasing headache days per month were inversely related with the presence of nausea, vomiting, phonophobia, and photophobia. Longer duration of headache (months) and higher visual analog scale (VAS) for headache intensity were associated with all accompanying symptoms. Phonophobia, nausea, photophobia, and vomiting were the most frequent accompanying symptoms (experienced by 80.2, 77.6, 71.2, and 40.9 % of patients, respectively). Osmophobia was also frequent in chronic migraine patients (53.4 %) and was closely associated with other accompanying symptoms. Vertigo and dizziness were observed less frequently, and they were not associated with accompanying symptoms. Conclusion: Phenotype of chronic migraine may be associated with the course of chronification. Duration of illness and attack intensity were closely related with the presence of accompanying symptoms, although headache frequency was found to be inversely related to the presence of accompanying symptoms. Osmophobia was also a frequent symptom and was closely related with other accompanied symptoms, unlike vertigo and dizziness. Inclusion of osmophobia into the diagnostic criteria might improve accurate diagnosis of chronic migraine.en_US
dc.description.sponsorshipTurkish Neurological Society; Allergan INC.Allerganen_US
dc.description.sponsorshipThis study is conducted as a part of Turkish Headache Database Project. Turkish Headache Database Project is supported by Turkish Neurological Society and unsolicited grant from Allergan INC.en_US
dc.identifier.doi10.1186/s10194-016-0616-yen_US
dc.identifier.issn1129-2369
dc.identifier.issn1129-2377
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/s10194-016-0616-y
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4101
dc.identifier.volume17en_US
dc.identifier.wosWOS:000372540100002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofJournal Of Headache And Painen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic migraineen_US
dc.subjectPhenotypeen_US
dc.subjectAccompanying symptomsen_US
dc.subjectChronificationen_US
dc.titlePhenotypic features of chronic migraineen_US
dc.typeArticleen_US

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