Synthesis and antimicrobial activity of 4-phenyl/cyclohexyl-5-(1-phenoxyethyl)-3-[N-(2-thiazolyl)acetamido]thio-4H-1,2,4-triazole derivatives

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dc.contributor.authorZitouni, Gülhan Turan
dc.contributor.authorKaplancıklı, Zafer Asım
dc.contributor.authorYıldız, Mehmet Taha
dc.contributor.authorChevallet, Pierre
dc.contributor.authorKaya, Demet
dc.date.accessioned2020-04-30T23:32:25Z
dc.date.available2020-04-30T23:32:25Z
dc.date.issued2005
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionKAPLANCIKLI, ZAFER ASIM/0000-0003-2252-0923; YILDIZ, Mehmet T/0000-0003-4768-0333en_US
dc.descriptionWOS: 000229895000010en_US
dc.descriptionPubMed: 15922844en_US
dc.description.abstractThe increasing clinical importance of drug-resistant fungal and bacterial pathogens has lent additional urgency to microbiological research and new antimicrobial compound development. For this purpose, new thiazole derivatives of triazoles were synthesized and evaluated for antifungal and antibacterial activity. The reaction of propionic acid hydrazides with various aryl/alkyl isothiocyanates gave thiosemicarbazides which furnished the mercaptotriazoles by alkali cyclization. The 4-phenyl/cyclohexyl-5-(1-phenoxyethyl)-3-[N-(2-thiazolyl)acetainido]thio-4H-1,2,4-triazole derivatives were synthesized by reacting the mercaptotriazoles with 2-chloi-o-N-(2-thiazolyl)acetamide. The chemical structures of the compounds were elucidated by IR, H-1-NMR, FAB(+)-MS spectral data. Their antimicrobial activities against Candida albicans (two strains), Candida glabrata, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa were investigated. The results showed that some of the compounds have very strong antifungal activity. (c) 2005 Elsevier SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejmech.2005.01.007en_US
dc.identifier.endpage613en_US
dc.identifier.issn0223-5234
dc.identifier.issn1768-3254
dc.identifier.issue6en_US
dc.identifier.startpage607en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2005.01.007
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4712
dc.identifier.volume40en_US
dc.identifier.wosWOS:000229895000010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofEuropean Journal Of Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectthiazoleen_US
dc.subjecttriazoleen_US
dc.subjectantifungal activityen_US
dc.subjectantibacterial activityen_US
dc.titleSynthesis and antimicrobial activity of 4-phenyl/cyclohexyl-5-(1-phenoxyethyl)-3-[N-(2-thiazolyl)acetamido]thio-4H-1,2,4-triazole derivativesen_US
dc.typeArticleen_US

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