Synthesis and antimicrobial activity of 4-phenyl/cyclohexyl-5-(1-phenoxyethyl)-3-[N-(2-thiazolyl)acetamido]thio-4H-1,2,4-triazole derivatives
Loading...
Files
Date
2005
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier France-Editions Scientifiques Medicales Elsevier
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
The increasing clinical importance of drug-resistant fungal and bacterial pathogens has lent additional urgency to microbiological research and new antimicrobial compound development. For this purpose, new thiazole derivatives of triazoles were synthesized and evaluated for antifungal and antibacterial activity. The reaction of propionic acid hydrazides with various aryl/alkyl isothiocyanates gave thiosemicarbazides which furnished the mercaptotriazoles by alkali cyclization. The 4-phenyl/cyclohexyl-5-(1-phenoxyethyl)-3-[N-(2-thiazolyl)acetainido]thio-4H-1,2,4-triazole derivatives were synthesized by reacting the mercaptotriazoles with 2-chloi-o-N-(2-thiazolyl)acetamide. The chemical structures of the compounds were elucidated by IR, H-1-NMR, FAB(+)-MS spectral data. Their antimicrobial activities against Candida albicans (two strains), Candida glabrata, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa were investigated. The results showed that some of the compounds have very strong antifungal activity. (c) 2005 Elsevier SAS. All rights reserved.
Description
KAPLANCIKLI, ZAFER ASIM/0000-0003-2252-0923; YILDIZ, Mehmet T/0000-0003-4768-0333
WOS: 000229895000010
PubMed: 15922844
WOS: 000229895000010
PubMed: 15922844
Keywords
thiazole, triazole, antifungal activity, antibacterial activity
Journal or Series
European Journal Of Medicinal Chemistry
WoS Q Value
Q2
Scopus Q Value
Volume
40
Issue
6
