Protection of Saphenous Vein Graft from Arterial Pressure An Experimental Study

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dc.contributor.authorKurdal, Adnan Taner
dc.contributor.authorÜstündağ, Nil
dc.contributor.authorGüven, Aysel
dc.contributor.authorİşkesen, İhsan
dc.contributor.authorBozkurt, K.
dc.contributor.authorŞirin, Bekir Hayrettin
dc.date.accessioned2020-04-30T23:21:50Z
dc.date.available2020-04-30T23:21:50Z
dc.date.issued2009
dc.departmentDÜ, Tıp Fakültesien_US
dc.descriptionWOS: 000270507400004en_US
dc.descriptionPubMed: 19707974en_US
dc.description.abstractBackground: Reoperations for bypass surgery increase the need for new grafts. We investigated early changes in both the normal human saphenous vein and in ectatic varicose veins externally supported by PTFE (polytetrafluoroethylene) graft and exposed to arterial pressure in an in vitro non-pulsatile flow model. Material and Methods: A total of 24 saphenous vein pieces (11 of them normal, the other 13 with varicosities) with a length of 6 centimeters were divided into equal parts: half of these parts were wrapped in PTFE grafts. All vein parts were placed in a perfusion circuit. Tissue biopsies were obtained from the vein segments. Light and electron microscopy examinations were performed, and endothelial continuity, elastic laminate continuity, medial connective tissue uniformity, medial smooth muscle uniformity, and adventitial connective tissue uniformity parameters were identified. Results: All parameters in the PTFE protected vein groups were better. The fewest morphological changes among all four groups were detected in the vein walls from normal veins with PTFE protection. There was no significant difference in endothelial continuity and adventitial connective tissue uniformity between the normal vein group and the varicose vein group with PTFE protection. Conclusions: It is suggested that supporting vein grafts externally with PTFE sufficiently protects the vein walls against damage from exposure to arterial pressure. If varicose veins are used as arterial grafts, supporting them with PTFE may be useful because of the good protection of endothelial and medial connective tissues, resulting in similar parameters to those of normal vein walls.en_US
dc.identifier.doi10.1055/s-0029-1185597en_US
dc.identifier.endpage338en_US
dc.identifier.issn0171-6425
dc.identifier.issn1439-1902
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage333en_US
dc.identifier.urihttps://doi.org/10.1055/s-0029-1185597
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4258
dc.identifier.volume57en_US
dc.identifier.wosWOS:000270507400004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofThoracic And Cardiovascular Surgeonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsaphenous veinen_US
dc.subjectvaricose veinen_US
dc.subjectgraft patencyen_US
dc.subjectintimal injuryen_US
dc.titleProtection of Saphenous Vein Graft from Arterial Pressure An Experimental Studyen_US
dc.typeArticleen_US

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