Investigation of Monnose-Binding Lectin gene Polymorphism in Patients with Erythema Multiforme, Stevens-Johnson Syndrome and Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Syndrome

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dc.contributor.authorKarkucak, Mutlu
dc.contributor.authorBülbül, Emel Başkan
dc.contributor.authorTuran, Hakan
dc.contributor.authorYakut, Tahsin
dc.contributor.authorToka, Sevil
dc.contributor.authorSarıcaoğlu, Hayriye
dc.date.accessioned2020-04-30T23:18:38Z
dc.date.available2020-04-30T23:18:38Z
dc.date.issued2012
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000315506200017en_US
dc.descriptionPubMed: 25207021en_US
dc.description.abstractObjective: Monnose-Binding lectin (MBL) appears to play an important role in the immune system. The genetic polymorphisms in the MBL2 gene can result in a reduction of serum levels, leading to a predisposition to recurrent infection. The aim of this study is to investigate the influence of a polymorphism in codon 54 of the MBL2 gene on the susceptibility to Erythema Multiforme, Stevens-Johnson Syndrome and Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Syndrome (EM, SJS and SJS/TEN overlap syndrome). Material and Methods: Our study included 64 patients who were clinically and/or histopathologically diagnosed with EM, SJS, and SJS/TEN overlap syndrome and 66 healthy control subjects who were genotyped for the MBL2 gene codon 54 polymorphism using the PCR-RFLP method. For all statistical analyses, the level of significance was set at p<0.05. Results: The prevalence of the B allele was 18% in the EM, SJS and SJS/TEN patient groups and 13% in the control group. No significant differences in allele frequencies of any polymorphism were observed between the patient and control groups, although the B allele was more frequent in the patient groups (p=0.328). Conclusion: Our results provide no evidence of a relationship between MBL2 gene codon 54 polymorphism and the susceptibility to EM, SJS and SJS/TEN overlap syndrome. However, these findings should be confirmed in studies with a larger sample size.en_US
dc.identifier.doi10.5152/balkanmedj.2012.018en_US
dc.identifier.endpage313en_US
dc.identifier.issn2146-3123
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage310en_US
dc.identifier.urihttps://doi.org/10.5152/balkanmedj.2012.018
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3449
dc.identifier.volume29en_US
dc.identifier.wosWOS:000315506200017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAves Yayinciliken_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPolymorphismen_US
dc.subjectMBL2 geneen_US
dc.subjectErythema multiformeen_US
dc.subjectStevens-Johnson syndromeen_US
dc.subjectStevens-Johnson syndrome/toxic epidermal necrolysis overlap syndromeen_US
dc.titleInvestigation of Monnose-Binding Lectin gene Polymorphism in Patients with Erythema Multiforme, Stevens-Johnson Syndrome and Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Syndromeen_US
dc.typeArticleen_US

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