Is there any relationship between quality of life and polysomnographically detected sleep parameters/disorders in stable myasthenia gravis?

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dc.contributor.authorTaşçılar, Nida Fatma
dc.contributor.authorSaracli, Özge
dc.contributor.authorKurçer, Mehmet Ali
dc.contributor.authorAnkaralı, Handan
dc.contributor.authorEmre, Ufuk
dc.date.accessioned2020-04-30T23:18:46Z
dc.date.available2020-04-30T23:18:46Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionAnkarali, Handan Camdeviren/0000-0002-3613-0523; Tascilar, Nida/0000-0003-0780-0783en_US
dc.descriptionWOS: 000427844400006en_US
dc.descriptionPubMed: 28456888en_US
dc.description.abstractIt is known that quality of life in myasthenia gravis is positively correlated with subjective sleep quality, still no data is available regarding the relationship between QOL and polysomnographically detected sleep parameters and disorders. In this study, we tried to highlighten this relationship, by performing polysomnography. Sleep-related complaints were evaluated in face-to-face interviews with 19 clinically stable MG patients and 26 healthy controls. During the interviews questionnaires assessing sleep quality, excessive daytime sleepiness, fatigue, depression, anxiety, and Turkish version of the MG-QOL 15-item scale [(MG-QOL15(T)] were administered and then an overnight polysomnography was performed. Sleep disorders, especially obstructive sleep apnea and fatigue were higher, whereas subjective sleep duration was significantly lower, in patients than controls. Excessive daytime sleepiness and poor sleep quality were not different between patients and controls. Other than percentage of sleep stage III, which was negatively correlated with MG-QOL15(T) scores, neither other sleep parameters nor sleep disorders were correlated with MG-QOL15(T) scores. MG composite, subjective sleep duration, fatigue severity and Hamilton depression rating scale scores were found to be positively correlated with MG-QOL15(T) scores. It was shown that decreasing disease severity and enhancing psychological well-being will improve patients' quality of life. We recommend that our findings should be repeated in a large prospective cohort of MG patients.en_US
dc.identifier.doi10.1007/s13760-017-0787-6en_US
dc.identifier.endpage37en_US
dc.identifier.issn0300-9009
dc.identifier.issn2240-2993
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.1007/s13760-017-0787-6
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3520
dc.identifier.volume118en_US
dc.identifier.wosWOS:000427844400006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofActa Neurologica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMyasthenia gravisen_US
dc.subjectSleep apneaen_US
dc.subjectQuality of lifeen_US
dc.subjectPolysomnographyen_US
dc.titleIs there any relationship between quality of life and polysomnographically detected sleep parameters/disorders in stable myasthenia gravis?en_US
dc.typeArticleen_US

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