Effect of melatonin on kidney cold ischemic preservation injury

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dc.contributor.authorAslaner, Arif
dc.contributor.authorGünal, Ömer
dc.contributor.authorTurgut, Hamdi Taner
dc.contributor.authorÇelik, Erdal
dc.contributor.authorYıldırım, Ümran
dc.contributor.authorDemirci, Rojbin Karakoyun
dc.contributor.authorDoğan, Sami
dc.date.accessioned2020-05-01T09:11:43Z
dc.date.available2020-05-01T09:11:43Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000327587600009en_US
dc.descriptionPubMed: 24179573en_US
dc.description.abstractMelatonin is a potent free radical scavenger of reactive oxygen species, nitric oxide synthase inhibitor and a well-known antioxidant secreted from pineal gland. This hormone has been reported to protect tissue from oxidative damage. In this study, we aim to investigate the effect of melatonin on kidney cold ischemia time when added to preservation solution. Thirty male Wistar albino rats were divided equally into three groups; Ringer Lactate (RL) solution, University of Wisconsin (UW) solution with and without melatonin. The serum Lactate Dehydrogenase (LDH) activities of the preservation solutions at 2nd, 24th, 36th, and 48th hours were determined. Tissue malondialdehyde (MDA) levels were also measured and a histological examination was performed at 48th hour. Melatonin that added to preservation solution prevented enzyme elevation and decreased lipid peroxidation in preservation solution when compared to the control group (p<0.05). The histological examination revealed that UW solution containing melatonin significantly prevented the kidney from pathological injury (p<0.05). Melatonin added to preservation solutions such as UW solution seemed to protect the tissue preserved effectively from cold ischemic injury for up to 48 hour.en_US
dc.identifier.endpage798en_US
dc.identifier.issn1940-5901
dc.identifier.issue9en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage794en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5736
dc.identifier.volume6en_US
dc.identifier.wosWOS:000327587600009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal Of Clinical And Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelatoninen_US
dc.subjectkidneyen_US
dc.subjectUniversity of Wisconsin solutionen_US
dc.subjectcold preservationen_US
dc.titleEffect of melatonin on kidney cold ischemic preservation injuryen_US
dc.typeArticleen_US

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