In vivo Comparison of the Effects of Bupivacaine and Levobupivacaine on the Pregnant Rat Myometrium Using Electrohysterogram

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dc.contributor.authorKaynak, Gürsel
dc.contributor.authorİskender, Abdülkadir
dc.contributor.authorAlbayrak, Mustafa
dc.contributor.authorAnkaralı, Seyit
dc.contributor.authorDemir, Şerif
dc.contributor.authorDemiraran, Yavuz
dc.contributor.authorYalçın, Gülbin Sezen
dc.date.accessioned2020-04-30T23:18:28Z
dc.date.available2020-04-30T23:18:28Z
dc.date.issued2012
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionAnkarali, Seyit/0000-0003-3752-0846en_US
dc.descriptionWOS: 000299499100008en_US
dc.descriptionPubMed: 22086131en_US
dc.description.abstractBackground and Aims: The effect of local anesthetics on myometrial contractility during labor analgesia is debatable. We aimed to compare the effects of bupivacaine and levobupivacaine on rat uterine contractility in an in vivo setting. Methods: Electrical activities of 40 pregnant rat uteruses were recorded on electrohysterogram after dividing the rats into bupivacaine and levobupivacaine groups. Uterine contraction frequencies were recorded at each 5-min interval. The first 5-min recording was considered the control, which was immediately followed by intramyometrial administration of either bupivacaine or levobupivacaine. The recordings were continued for 30 min. The changes in frequencies at each time interval of the groups were compared with each other and the control recording. Results: The frequencies from both groups at each interval were lower than the control values, but not different between the groups. The frequencies of the bupivacaine group during the 5-10 min and 10-15 min intervals were lower than the control time interval, but no significant differences were present between the control and the other time intervals. However, no significant differences were found at any time interval for the levobupivacaine group. Conclusion: Levobupivacaine led to less muscle relaxation compared to bupivacaine and may be a better option for labor analgesia and anesthesia considering uterine contractility. Copyright (C) 2011 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000329332en_US
dc.identifier.endpage47en_US
dc.identifier.issn0378-7346
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage43en_US
dc.identifier.urihttps://doi.org/10.1159/000329332
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3331
dc.identifier.volume73en_US
dc.identifier.wosWOS:000299499100008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofGynecologic And Obstetric Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLabor analgesiaen_US
dc.subjectBupivacaineen_US
dc.subjectLevobupivacaineen_US
dc.titleIn vivo Comparison of the Effects of Bupivacaine and Levobupivacaine on the Pregnant Rat Myometrium Using Electrohysterogramen_US
dc.typeArticleen_US

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