Gentamicin-induced nephrotoxicity in rats ameliorated and healing effects of resveratrol

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dc.contributor.authorSılan, Coşkun
dc.contributor.authorUzun, Özge
dc.contributor.authorÇomunoğlu, Nil Üstündağ
dc.contributor.authorGökçen, Sanem
dc.contributor.authorBedirhan, Selma
dc.contributor.authorCengiz, Müjgan
dc.date.accessioned2020-05-01T12:10:14Z
dc.date.available2020-05-01T12:10:14Z
dc.date.issued2007
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionSilan, Coskun/0000-0002-8352-6571; cengiz, mujgan/0000-0003-1030-5425; silan, coskun/0000-0002-8352-6571en_US
dc.descriptionWOS: 000243960400016en_US
dc.descriptionPubMed: 17202664en_US
dc.description.abstractIn this study, we aimed to investigate the possible protective effect of resveratrol on gentamicin induced nephrotoxicity. Experiments were carried out in male Wistar rats weighing 200-250g. Gentamicin sulfate (80 mg/kg per day i.p.), resveratrol (10 mg/kg per day i.p.) and gentamicin together with resveratrol were administered for 6 d. The animals were sacrificed 24 h after the last injection. Urine, blood samples and tissue samples were collected from the animals on the seventh day of the treatment before they were sacrificed. Kidneys were collected for histopathological studies and fixed in 10% buffered formalin solution. Tissue samples were stored at -70 degrees C in liquid nitrogen for the determination of glutathione (GSH), glutathione-S-transferase (GST), malondialdehyde (MDA) and catalase (CAT). Glutathione assay was determined by the method of Beutler et al. GST amounts were measured by the method of Habig et al. Catalase activitiy was tested by Aebi's method and MDA was determined according to Thayer's method. Blood urea level was significantly increased in the gentamicin treated group. The study showed lowered levels of urea and creatinine levels in resveratrol administered groups when compared with gentamicin administered rats, and the difference was statistically significant. It has been determined that resveratrol caused statistically significant decrease in lipid peroxidation and reduced the level of catalase. Histopathological examination showed that resveratrol prevented partly gentamicin induced tubular damage. The results histopathologically demonstrated that resveratrol has a protective effect against gentamicin induced nephrotoxicity, lipid peroxidation and cellular damage in rats.en_US
dc.identifier.doi10.1248/bpb.30.79en_US
dc.identifier.endpage83en_US
dc.identifier.issn0918-6158
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage79en_US
dc.identifier.urihttps://doi.org/10.1248/bpb.30.79
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6095
dc.identifier.volume30en_US
dc.identifier.wosWOS:000243960400016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPharmaceutical Soc Japanen_US
dc.relation.ispartofBiological & Pharmaceutical Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectresveratrolen_US
dc.subjectgentamicinen_US
dc.subjectnephrotoxicityen_US
dc.subjectlipid peroxidationen_US
dc.subjectantioxidanten_US
dc.titleGentamicin-induced nephrotoxicity in rats ameliorated and healing effects of resveratrolen_US
dc.typeArticleen_US

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