Clinical and cognitive profiles of patients with both Parkinson's disease and essential tremor

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dc.contributor.authorBarut, Banu Özen
dc.contributor.authorGünal, Dilek İnce
dc.contributor.authorTürkmen, Çiğdem
dc.contributor.authorMollahasanoğlu, Aynur
dc.contributor.authorAnkaralı, Handan
dc.date.accessioned2020-04-30T22:40:50Z
dc.date.available2020-04-30T22:40:50Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionAnkarali, Handan Camdeviren/0000-0002-3613-0523en_US
dc.descriptionWOS: 000319357200002en_US
dc.descriptionPubMed: 22926528en_US
dc.description.abstractAlthough Parkinson's disease (PD) and essential tremor (ET) are distinct clinical disorders, their coexistence can sometimes cause diagnostic problems. In this study, we conducted detailed investigations of patients with both ET and PD (ET-PD) and compared their clinical and cognitive profiles with those of patients with only ET or only PD. This study examined three groups of patients: the first group had ET-PD concomitantly (n = 9); the second group had only ET (n = 9); the third group had only PD (n = 10). The groups were compared in terms of demographic characteristics, clinical features, and cognitive functions. With the exception of positive family histories, which were more common in ET-PD than in PD patients, we found no differences among the groups with respect to demographic characteristics (p = 0.044). PD-only patients had more akinetic-rigid type Parkinsonism (p = 0.016), and their levodopa response was better than that of ET-PD patients (p = 0.017). Patients with ET-PD obtained significantly lower scores than those with pure ET on several cognitive tests, suggesting a prominent frontal-type cognitive dysfunction. In conclusion ET-PD patients differed from PD patients, showing more frequent familial tremor histories and lower levodopa responsiveness. This patient population also demonstrated more severe cognitive impairments than pure-ET patients. This result suggests that ET-PD patients are a subset of ET patients with more widespread neurodegeneration, which may indicate the presence of a syndrome that includes overlap between ET and PD.en_US
dc.identifier.doi10.1007/s13760-012-0124-zen_US
dc.identifier.endpage125en_US
dc.identifier.issn0300-9009
dc.identifier.issn2240-2993
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage117en_US
dc.identifier.urihttps://doi.org/10.1007/s13760-012-0124-z
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3069
dc.identifier.volume113en_US
dc.identifier.wosWOS:000319357200002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofActa Neurologica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectParkinson's diseaseen_US
dc.subjectEssential tremoren_US
dc.subjectCognitionen_US
dc.subjectTremoren_US
dc.titleClinical and cognitive profiles of patients with both Parkinson's disease and essential tremoren_US
dc.typeArticleen_US

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