Value of Argyrophilic Nucleolar Organizing Region Protein Determinations in Nondiagnostic Fine Needle Aspiration Samples (Due to Insufficient Cell Groups) of Thyroid Nodules

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dc.contributor.authorEröz, Recep
dc.contributor.authorÜnlühizarcı, Kürşad
dc.contributor.authorCücer, Nurhan
dc.contributor.authorÖztürk, Figen
dc.date.accessioned2020-04-30T23:46:53Z
dc.date.available2020-04-30T23:46:53Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000326422900007en_US
dc.descriptionPubMed: 24341126en_US
dc.description.abstractOBJECTIVE: To evaluate the diagnostic value of argyrophilic nucleolar organizing regions (AgNORs) in the nondiagnostic fine needle aspiration biopsy (NFNAB) specimens (due to insufficient cell groups) of cases with thyroid nodules. STUDY DESIGN: Thirty-five patients with NFNAB were included in the study. FNAB stained with Giemsa was faded using the McKee technique, then stained for AgNOR detection according to a specific protocol. One hundred nuclei per individual were evaluated to detect the AgNOR count/nucleus and total AgNOR area/nuclear area (TNA/NA) of individual cells by using a computer program. RESULTS: The AgNOR values of patients with NFNAB were between 1.2-2.4% for AgNOR count/nucleus and between 3.1-9.1% for TNA/NA. When the cutoff values were taken as >3 for AgNOR count/nucleus and >8 for TNA/NA, the sensitivity ratios were 100% and 97% for AgNOR count/nucleus and TNA/NA for discriminating benign/malignant lesions. CONCLUSION: By using some cutoff values obtained from a modified AgNOR staining method, benign/malignant potential of thyroid aspirations with NFNAB may be estimated.en_US
dc.identifier.endpage231en_US
dc.identifier.issn0884-6812
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage226en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5346
dc.identifier.volume35en_US
dc.identifier.wosWOS:000326422900007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical And Quantitative Cytology And Histologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgNORsen_US
dc.subjectargyrophilic nucleolar organizer region associated proteinsen_US
dc.subjectNOR antigensen_US
dc.subjectrDNAen_US
dc.subjectthyrocyteen_US
dc.titleValue of Argyrophilic Nucleolar Organizing Region Protein Determinations in Nondiagnostic Fine Needle Aspiration Samples (Due to Insufficient Cell Groups) of Thyroid Nodulesen_US
dc.typeArticleen_US

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