Value of Argyrophilic Nucleolar Organizing Region Protein Determinations in Nondiagnostic Fine Needle Aspiration Samples (Due to Insufficient Cell Groups) of Thyroid Nodules
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Date
2013
Journal Title
Journal ISSN
Volume Title
Publisher
Sci Printers & Publ Inc
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
OBJECTIVE: To evaluate the diagnostic value of argyrophilic nucleolar organizing regions (AgNORs) in the nondiagnostic fine needle aspiration biopsy (NFNAB) specimens (due to insufficient cell groups) of cases with thyroid nodules. STUDY DESIGN: Thirty-five patients with NFNAB were included in the study. FNAB stained with Giemsa was faded using the McKee technique, then stained for AgNOR detection according to a specific protocol. One hundred nuclei per individual were evaluated to detect the AgNOR count/nucleus and total AgNOR area/nuclear area (TNA/NA) of individual cells by using a computer program. RESULTS: The AgNOR values of patients with NFNAB were between 1.2-2.4% for AgNOR count/nucleus and between 3.1-9.1% for TNA/NA. When the cutoff values were taken as >3 for AgNOR count/nucleus and >8 for TNA/NA, the sensitivity ratios were 100% and 97% for AgNOR count/nucleus and TNA/NA for discriminating benign/malignant lesions. CONCLUSION: By using some cutoff values obtained from a modified AgNOR staining method, benign/malignant potential of thyroid aspirations with NFNAB may be estimated.
Description
WOS: 000326422900007
PubMed: 24341126
PubMed: 24341126
Keywords
AgNORs, argyrophilic nucleolar organizer region associated proteins, NOR antigens, rDNA, thyrocyte
Journal or Series
Analytical And Quantitative Cytology And Histology
WoS Q Value
Q4
Scopus Q Value
N/A
Volume
35
Issue
4
