Do non-steroidal anti-inflammatory agents prevent stenotic complications of tracheal surgery? The effects of tenoxicam on tracheal healing

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dc.contributor.authorGezer, Suat
dc.contributor.authorKarapolat, Bekir Sami
dc.contributor.authorYıldırım, Ümran
dc.contributor.authorKandiş, Hayati
dc.contributor.authorAydın, Leyla Yılmaz
dc.date.accessioned2020-05-01T09:11:28Z
dc.date.available2020-05-01T09:11:28Z
dc.date.issued2011
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionKandis, Hayati/0000-0001-9151-6050en_US
dc.descriptionWOS: 000293479500020en_US
dc.description.abstractBackground: Postoperative strictures, which are still serious problems of tracheal surgery, are caused by an inflammatory reaction with subsequent edema and granulation tissue formation. Taking this into consideration, we have designed a study in which tenoxicam (potent, non-steroidal, anti-inflammatory drug) was used after a tracheal surgery in rats. Methods: Fourteen female Wistar rats were randomly divided into two groups (tenoxicam and control group) with equal numbers. Ketamine-xylazine anesthesia was performed in the rats. A vertical incision on the anterior tracheal wall, including the third to fifth cartilaginous rings, was performed and closed primarily with an interrupted suture technique using 4/0 absorbable suture. The tenoxicam group was administered 0.5 mg/kg/day tenoxicam and the control group was given 0.5 cc/day 0.9% NaCl via intraperitoneal route for 10 days beginning from the operation day. After two weeks, all animals were sacrificed under general anesthesia. Tracheas were excised, and a pathologist blindly evaluated the cases. The Mann-Whitney U-test was used for statistical analysis, and a value of p<0.05 was considered significant. Results: The rat specimens were histologically evaluated and scored for inflammatory cell infiltration, angiogenesis, fibroblast proliferation, collagen deposition, and epithelial regeneration. There were meaningful differences in fibroblast proliferation (p=0.036) and epithelial regeneration (p=0.002). These results show that epithelial regeneration was higher and fibroblast proliferation was lower in the tenoxicam group. Conclusion: Increased fibroblastic activity causes stenosis after tracheal surgery and the application of tenoxicam diminishes fibroblast proliferation and improves epithelial healing. Therefore, postoperative non-steroidal anti-inflammatory drug usage might be a useful therapy in the prevention of stenotic complications after tracheal surgery. However, further studies are needed.en_US
dc.identifier.doi10.5606/tgkdc.dergisi.2011.055en_US
dc.identifier.endpage428en_US
dc.identifier.issn1301-5680
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage425en_US
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2011.055
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5605
dc.identifier.volume19en_US
dc.identifier.wosWOS:000293479500020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherEkin Tibbi Yayincilik Ltd Sti-Ekin Medical Publen_US
dc.relation.ispartofTurk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal Of Thoracic And Cardiovascular Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStructureen_US
dc.subjecttenoxicamen_US
dc.subjecttracheal healingen_US
dc.subjecttracheal surgeryen_US
dc.titleDo non-steroidal anti-inflammatory agents prevent stenotic complications of tracheal surgery? The effects of tenoxicam on tracheal healingen_US
dc.typeArticleen_US

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