Effects of tranexamic acid on the recovery of osteochondral defects treated by microfracture and acellular matrix scaffold: an experimental study

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dc.contributor.authorDeğirmenci, Erdem
dc.contributor.authorÖzturan, Kutay Engin
dc.contributor.authorŞahin, Abdullah Alper
dc.contributor.authorYılmaz, Fahri
dc.contributor.authorKaya, Yasin Emre
dc.date.accessioned2020-05-01T09:12:06Z
dc.date.available2020-05-01T09:12:06Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionDEGIRMENCI, ERDEM/0000-0002-7988-4261en_US
dc.descriptionWOS: 000464895500001en_US
dc.descriptionPubMed: 30992060en_US
dc.description.abstractBackground: Microfracture and scaffold application in the treatment of osteochondral defects is still one of the most frequently used methods in the clinic. The most important step in this treatment method is the stabilization of fibrin clot Tranexamic acid (TA) is an antifibrinolytic agent commonly used in orthopedic surgery in recent years. This study evaluated the effect of local TA application on healing of experimentally induced osteochondral defects on rabbits. Methods: This paper contains an animal in vivo data and histological outcomes on the effect of TA. Eighteen New Zealand white rabbits were treated unilaterally and cylindrical defects having a width of 4 mm and depth of 5 mm were created in the weight-bearing surfaces of the medial and lateral condyles of the right femur. They were divided into two groups, as group 1 study and group 2 control groups, respectively. One milliliter (ml) of TA was injected into the knee joints of the subjects in group 1. All animals were sacrificed for the extraction of the femur condyles for histologic study at the fourth and eighth weeks after surgery. Histological evaluations were performed by Brittberg and O'Driscoll scores to all samples. Data were organized in a Standard Statistical Package System v.22 software package (SPSS/PC Inc., Chicago, IL) and reported as mean and median (min-max). Repeated measures ANOVA test was used to compare groups and condyle effects together for each week. p values below 0.05 were considered as statistically significant. Results: Samples were taken in the fourth and eighth weeks. The regularity of the surface in group 1 was smoother, and the tissue stability was more robust. Mean Brittberg scores in both weeks were statistically higher in group 1 when compared with group 2. In the microscopic evaluation, it was observed that the regeneration of subchondral and cartilage tissues were more rapid and organized in group 1, and the mean O' Driscoll scores in both weeks were statistically higher in group 1. Conclusions: Application of TA improves the healing time and tissue stability in osteochondral defects which are implanted a-cellular scaffold after microfracture and should be applicable to humans for the treatment of osteochondral defects.en_US
dc.description.sponsorshipDuzce University Scientific Research Projects Support Funden_US
dc.description.sponsorshipAnimals were obtained from the experimental animal care center of AIBU with the support of Duzce University Scientific Research Projects Support Fund.en_US
dc.identifier.doi10.1186/s13018-019-1144-7en_US
dc.identifier.issn1749-799X
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/s13018-019-1144-7
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5875
dc.identifier.volume14en_US
dc.identifier.wosWOS:000464895500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofJournal Of Orthopaedic Surgery And Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOsteochondral defecten_US
dc.subjectMicrofractureen_US
dc.subjectA-cellular scaffolden_US
dc.subjectTranexamic aciden_US
dc.titleEffects of tranexamic acid on the recovery of osteochondral defects treated by microfracture and acellular matrix scaffold: an experimental studyen_US
dc.typeArticleen_US

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