The Effect of Neuronal Nitric Oxide Synthase Inhibitor 7-Nitroindazole on the Cell Death Induced by Zinc Administration in the Brain of Rats

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dc.contributor.authorGökçe, M. Fatih
dc.contributor.authorBağırıcı, Faruk
dc.contributor.authorDemir, Şerif
dc.contributor.authorBostancı, M. Ömer
dc.contributor.authorGüven, Aysel
dc.date.accessioned2020-04-30T23:33:03Z
dc.date.available2020-04-30T23:33:03Z
dc.date.issued2009
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionBOSTANCI, Mehmet Omer/0000-0002-2887-1073en_US
dc.descriptionWOS: 000265263900007en_US
dc.description.abstractAim: To evaluate the effect of the neuronal nitric oxide synthase (nNOS) inhibitor 7-nitroindazole (7-Nl) on hippocampal cell loss induced by zinc hemisulfate salt (ZnSO4-7H2O) treatment. Materials and Methods: Rats were divided into 3 groups (n = 21; 7 rats in each group): Control, Zinc, and Zinc+7-NI. In the Zinc and Zinc+7-NI (pretreatment) groups, ZnSO4-7H2O was applied intracortically to the left sensory motor cortex. The 7-Nl (50 mg/kg) was injected into the third group (Zinc+7-NI) intraperitoneally 20 min prior to zinc application and daily for the next 7 days. Cell loss in the left and right hippocampal hemispheres was quantified by optical fractionator. which is a relatively unbiased and reliable stereological counting method. Results: Zinc produced decreases of 43.5% and 46.1 % in the number of viable neurons in the left and right hippocampal hemispheres, respectively, in comparison with control values. In the Zinc+7-NI group, cell losses were 16.2% and 18.5% in the left and right hemispheres. respectively, in the same conditions. Thus, 7-Nl exerted a significant neuroprotective effect against zinc-induced cell loss in the rat hippocampus (P < 0.05). Conclusions: These results suggest that nitric oxide contributes to the hippocampal cell loss induced by zinc sulfate and that the prevention of nitric oxide formation by nNOS blockade can reduce this cell loss.en_US
dc.identifier.endpage202en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage197en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4884
dc.identifier.volume39en_US
dc.identifier.wosWOS:000265263900007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectZincen_US
dc.subjectcell deathen_US
dc.subjecthippocampusen_US
dc.subject7-nitroindazoleen_US
dc.subjectstereologyen_US
dc.subjectraten_US
dc.titleThe Effect of Neuronal Nitric Oxide Synthase Inhibitor 7-Nitroindazole on the Cell Death Induced by Zinc Administration in the Brain of Ratsen_US
dc.typeArticleen_US

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