DOES HIGHER NORs EXPRESSION AFFECT THE DEVELOPMENTAL STAGES OF DOWN SYNDROME INFANTS?

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dc.contributor.authorEröz, Recep
dc.contributor.authorOkur, M.
dc.contributor.authorÖzkan, A.
dc.contributor.authorBerik, O.
dc.contributor.authorGüneş, C.
dc.date.accessioned2020-05-01T09:11:28Z
dc.date.available2020-05-01T09:11:28Z
dc.date.issued2012
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000306574200014en_US
dc.descriptionPubMed: 22876584en_US
dc.description.abstractDoes higher NORs expression affect the developmental stages of Down syndrome infants?: Background: The nucleolar organizer regions (NORs) are localized at the secondary constriction of the five pairs of acrocentric chromosomes (13, 14, 15,21 and 22) in human. Materials and Methods: To evaluate whether increasing AgNOR protein synthesis effects or not the development of babies/children, 25 Down syndrome patients were included in this study. Firstly, the Ankara Development Screening Inventory (AGTE) test was performed. Then the buccal epithelial cells of patients were taken via a sterile toothpick on clean glass slides and spreaded and AgNOR staining technique was applied to the slides of each individual. Mean NOR area/Total nucleus area (NORa/TNa) were evaluated for each nucleus using a special computer program. Results: The mean NORa/TNa was found to be 3.8 +/- 1.16. According to these data, a significant correlation was not evident between the NORa/TNa and developmental stages (p > 0.05). Conclusions: There is no correlation between extra energy spending for NOR protein synthesis and developmental deficiency.en_US
dc.identifier.endpage253en_US
dc.identifier.issn1015-8146
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage249en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5611
dc.identifier.volume23en_US
dc.identifier.wosWOS:000306574200014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMedecine Et Hygieneen_US
dc.relation.ispartofGenetic Counselingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNORen_US
dc.subjectAgNORen_US
dc.subjectrDNAen_US
dc.subjectDown syndromeen_US
dc.titleDOES HIGHER NORs EXPRESSION AFFECT THE DEVELOPMENTAL STAGES OF DOWN SYNDROME INFANTS?en_US
dc.typeArticleen_US

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