DOES HIGHER NORs EXPRESSION AFFECT THE DEVELOPMENTAL STAGES OF DOWN SYNDROME INFANTS?
Küçük Resim Yok
Tarih
2012
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Medecine Et Hygiene
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Does higher NORs expression affect the developmental stages of Down syndrome infants?: Background: The nucleolar organizer regions (NORs) are localized at the secondary constriction of the five pairs of acrocentric chromosomes (13, 14, 15,21 and 22) in human. Materials and Methods: To evaluate whether increasing AgNOR protein synthesis effects or not the development of babies/children, 25 Down syndrome patients were included in this study. Firstly, the Ankara Development Screening Inventory (AGTE) test was performed. Then the buccal epithelial cells of patients were taken via a sterile toothpick on clean glass slides and spreaded and AgNOR staining technique was applied to the slides of each individual. Mean NOR area/Total nucleus area (NORa/TNa) were evaluated for each nucleus using a special computer program. Results: The mean NORa/TNa was found to be 3.8 +/- 1.16. According to these data, a significant correlation was not evident between the NORa/TNa and developmental stages (p > 0.05). Conclusions: There is no correlation between extra energy spending for NOR protein synthesis and developmental deficiency.
Açıklama
WOS: 000306574200014
PubMed: 22876584
PubMed: 22876584
Anahtar Kelimeler
NOR, AgNOR, rDNA, Down syndrome
Kaynak
Genetic Counseling
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
23
Sayı
2
