Extracorporeal Shockwave Increases the Effectiveness of Systemic Antibiotic Treatment in Implant-Related Chronic Osteomyelitis: Experimental Study in a Rat Model

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dc.contributor.authorİnanmaz, Mustafa Erkan
dc.contributor.authorUslu, Mustafa
dc.contributor.authorIşık, Cengiz
dc.contributor.authorKaya, Ertuğrul
dc.contributor.authorTaş, Tekin
dc.contributor.authorBayram, Recep
dc.date.accessioned2020-05-01T12:10:02Z
dc.date.available2020-05-01T12:10:02Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionKaya, Ertugrul/0000-0003-0081-682Xen_US
dc.descriptionWOS: 000333716100003en_US
dc.descriptionPubMed: 24676969en_US
dc.description.abstractImplant-related chronic osteomyelitis is a serious complication of orthopedic surgery requiring implant removal and radical debridement. Extracorporeal shockwave (ESW) have demonstrated significant bactericidal effectiveness in vitro and effectiveness and safety were evaluated in an animal model of osteomyelitis. In this experimental study, we aimed to test our hypothesis that the use of ESW together with systemic antibiotic treatment will provide synergy for the treatment of implant-related chronic osteomyelitis caused by methicillin-susceptible Staphylococcus aureus (MSSA). The proximal tibia of 32 rats was contaminated with (10)8CFU/ml methicillin-sensitive S. aureus (MSSA-ATCC 29213) and Kirschner-wires were placed into the medulla of the tibia. After 4 weeks, Kirschner-wires were removed and the rats were randomly divided into four groups: group I, untreated contaminated control group; group II, receiving only ESW therapy; group III, receiving only systemic teicoplanin; group IV, treated with a combination of ESW and systemic teicoplanin. ESW was applied twice to the infected limbs and all rats were sacrificed at the end of 8th week. The degree of tibial osteomyelitis was assessed by quantitative culture analysis. Bacterial counts in groups III and IV were significantly reduced relative to the control (p=0.002 and 0.001, respectively). The decrease in bacterial counts was more pronounced and significant in group IV compared to group III (p=0.024). In group II, bacterial counts also decreased, but the differences were in significant (p=0.068). Our experimental model suggests that ESW provides significant synergy for systemic antibiotic treatment. However, further clinical trials are required in order to use this treatment modality safely in patients, even though our study demonstrated successful results in the treatment of implant-related chronic osteomyelitis in rats. (c) 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:752-756, 2014.en_US
dc.identifier.doi10.1002/jor.22604en_US
dc.identifier.endpage756en_US
dc.identifier.issn0736-0266
dc.identifier.issn1554-527X
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage752en_US
dc.identifier.urihttps://doi.org/10.1002/jor.22604
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5942
dc.identifier.volume32en_US
dc.identifier.wosWOS:000333716100003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Orthopaedic Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectextracorporeal shockwaveen_US
dc.subjectchronic osteomyelitisen_US
dc.subjectmethicilline-sensitive Staphylococcus aureusen_US
dc.subjectteicoplaninen_US
dc.titleExtracorporeal Shockwave Increases the Effectiveness of Systemic Antibiotic Treatment in Implant-Related Chronic Osteomyelitis: Experimental Study in a Rat Modelen_US
dc.typeArticleen_US

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