Total fertilization failure: is it the end of the story?

Basit Öğe Kaydı
dc.contributor.authorKahyaoğlu, İnci
dc.contributor.authorDemir, Berfu
dc.contributor.authorTürkkanı, Ayten
dc.contributor.authorÇınar, Özgür
dc.contributor.authorDilbaz, Serdar
dc.contributor.authorDilbaz, Berna
dc.contributor.authorMollamahmutoğlu, Leyla
dc.date.accessioned2020-04-30T23:34:54Z
dc.date.available2020-04-30T23:34:54Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000341829700005en_US
dc.descriptionPubMed: 24962788en_US
dc.description.abstractTo study parameters that could predict in-vitro fertilization (IVF) success in patients who experienced total fertilization failure (TFF) with intracytoplasmic sperm injection (ICSI) in their previous cycles. Cycle characteristics of patients with TFF (Group I, n = 136 cycles), cycles resulting in embryo transfer (ET) following TFF (Group II, n = 36 cycles) and recurrent TFF (Group III, n = 25 cycles) and were studied retrospectively. Demographic features, cycle characteristics of three groups were compared. Follicle count measuring 15-17 mm was significantly higher in group II when compared to group I (p = 0.02). Total number of retrieved oocytes and mature oocytes were significantly higher in group II when compared to groups I and III (p = 0.001). Estradiol level at oocyte pick up (OPU) day was significantly higher in group II when compared to group I (p = 0.02). When the characteristics of ET cycles and preceding TFF cycles of the same patient were compared, total number of retrieved oocytes (5.11 +/- 0.72 (95 % CI 3.69-6.52) vs. 11.44 +/- 1.60 (95 % CI 5.29-17.59)) and mature oocytes (3.26 +/- 3.66 (95 % CI 2.04-4.47) vs. 6.92 +/- 5.61 (95 % CI 5.09-8.75)) were found to be significantly lower in TFF cycles (p = 0.001). Five biochemical and 5 clinical pregnancies occurred while only 2 healthy babies were born, corresponding to a live birth rate 5.5 %. Increasing the number of retrieved and mature oocytes may increase the success of fertilization in patients with a history of previous failed fertilization. However, live birth rate is still low in embryo transfer cycles.en_US
dc.identifier.doi10.1007/s10815-014-0281-5en_US
dc.identifier.endpage1160en_US
dc.identifier.issn1058-0468
dc.identifier.issn1573-7330
dc.identifier.issue9en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1155en_US
dc.identifier.urihttps://doi.org/10.1007/s10815-014-0281-5
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5240
dc.identifier.volume31en_US
dc.identifier.wosWOS:000341829700005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofJournal Of Assisted Reproduction And Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTotal fertilization failureen_US
dc.subjectIntracytoplasmic sperm injectionen_US
dc.subjectMature oocyteen_US
dc.subjectPoor responderen_US
dc.subjectDiminished ovarian reserveen_US
dc.titleTotal fertilization failure: is it the end of the story?en_US
dc.typeArticleen_US

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