Specificity and sensitivity of differentiation antigens in superficial soft tissue tumors: comparison of SMA, calponin, H-caldesmon, C-Kit, PLAP and HPL

Basit Öğe Kaydı
dc.contributor.authorDurak, Haydar
dc.contributor.authorÇomunoğlu, Nil
dc.contributor.authorÇomunoğlu, Cem
dc.contributor.authorGüven, Aysel
dc.contributor.authorÇam, Meryem
dc.contributor.authorDervişoğlu, Sergülen
dc.contributor.authorEren, Bülent
dc.date.accessioned2020-04-30T23:32:09Z
dc.date.available2020-04-30T23:32:09Z
dc.date.issued2010
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000281778100003en_US
dc.descriptionPubMed: 21033622en_US
dc.description.abstractWe examined the expression pattern of smooth muscle actin (SMA), h-caldesmon (HCD), calponin (CALF), placental alkaline phosphatase (PLAP) and human placental lactogen (HPL) in benign and malignant spindle cell superficial soft tissue tumors in order to determine the role of these markers in differential diagnosis. Archival tissue from 38 patients with superficial smooth muscle cell and so-called fibrohistiocytic tumors (8 benign fibrous histiocytomas (BFHs), 6 dermatofibrosarcoma protuberans (DFPT), 9 malignant fibrous histiocytomas (MFHs), 9 leiomyomas (LMs) and 6 leiomyosarcomas (LMSs)) were immunostained with antibodies against SMA, HCD, CALF, PLAP and HPL. smooth muscle cell (SMC) tumors showed significantly high immunopositivity for HCD than that of so-called fibrohistiocytic tumors (p is less than or equal to 0.05) but 1/3 of DFPT and MFH cases and half of BFH cases also showed HCD immunopositivity; thus, this difference is debatable and not highly discriminative as expected. All tumor groups showed 100% immunopositivity for CALP. SMC tumors displayed significantly stronger and more widespread immunostaining pattern for PLAP than so-called fibrohistiocytic tumors (p<0.05). Superficial soft tissue tumors did not express c-kit. In conclusion, HCD and FLAP can be used as ancillary immunomarkers in differential diagnosis of SMC tumors (Tab. 2, Fig. 7, Ref. 37). Full Text in free PDF www.bmj.sk.en_US
dc.identifier.endpage438en_US
dc.identifier.issn0006-9248
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage432en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4626
dc.identifier.volume111en_US
dc.identifier.wosWOS:000281778100003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectImmunohistochemistryen_US
dc.subjecth-caldesmonen_US
dc.subjectplacental alkaline phosphataseen_US
dc.subjectsoft tissue tumorsen_US
dc.titleSpecificity and sensitivity of differentiation antigens in superficial soft tissue tumors: comparison of SMA, calponin, H-caldesmon, C-Kit, PLAP and HPLen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu