Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress

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dc.contributor.authorOksala, Niku K.J.
dc.contributor.authorEkmekçi, Fitnat Güler
dc.contributor.authorÖzsoy, Ergi
dc.contributor.authorKırankaya, Şerife
dc.contributor.authorKokkola, Tarja
dc.contributor.authorEmecen, Güzin
dc.contributor.authorAtalay, Mustafa
dc.date.accessioned2020-04-30T23:19:29Z
dc.date.available2020-04-30T23:19:29Z
dc.date.issued2014
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.descriptionKokkola, Tarja/0000-0002-3303-3912; Kaarniranta, Kai/0000-0003-2600-8679en_US
dc.descriptionWOS: 000350812500004en_US
dc.descriptionPubMed: 25462062en_US
dc.description.abstractHear shock proteins (HSPs), originally identified as heat-inducible gene products, are a family of highly conserved proteins that respond to a wide variety of stress including oxidative stress. Although both acute and chronic oxidative stress have been well demonstrated to induce HSP responses, Rae evidence is available whether increased HSP levels provide enhanced protection against oxidative stress under elevated yet sublethal temperatures. We studied relationships between oxidative stress and HSPs in a physiological model by using Garra rufa (doctor fish), a fish species naturally acclimatized to different thermal conditions. We compared fish naturally living in a hot spring with relatively high water temperature (34.4 +/- 0.6 degrees C) to those living in normal river water temperature (25.4 +/- 4.7 degrees C), and found that levels of all the studied HSPs (HSP70, RSPB, HSP90, HSC70 and GRP75) were higher in fish living in elevated water temperature compared with normal river water temperature. In contrast, indicators of oxidative stress, including protein carbonyls and lipid hydroperoxides, were decreased in fish living in the elevated temperature, indicating that HSP levels are inversely associated with oxidative stress. The present results provide evidence that physiologically increased HSP levels provide protection against oxidative stress and enhance cyLoprotection. (C) 2014 The Authors. Published by Elsevier B.V.en_US
dc.description.sponsorshipFinnish Ministry of Education and Culture, Juho Vainio; Yrjo Jahnsson Foundations, Helsinki, Finland, High technology Foundation of eastern Finlanden_US
dc.description.sponsorshipThis work has been supported by the grants from the Finnish Ministry of Education and Culture, Juho Vainio and Yrjo Jahnsson Foundations, Helsinki, Finland, High technology Foundation of eastern Finland. University of Hacettepe. Unit of Scientific Researches (0202601006) and COST actions CM1001 "Chemistry of non-enzymatic protein modification - modulation of protein structure and function" and TD1304 "Zinc-Net". We thank Taina Vihavainen and Taija Hukkanen for the skillful technical assistance,en_US
dc.identifier.doi10.1016/j.redox.2014.10.003en_US
dc.identifier.endpage28en_US
dc.identifier.issn2213-2317
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage25en_US
dc.identifier.urihttps://doi.org/10.1016/j.redox.2014.10.003
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3770
dc.identifier.volume3en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofRedox Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThermalen_US
dc.subjectOxidationen_US
dc.subjectStressen_US
dc.subjectRegulationen_US
dc.subjectGarra rufaen_US
dc.titleNatural thermal adaptation increases heat shock protein levels and decreases oxidative stressen_US
dc.typeArticleen_US

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