Biological evaluation of benzothiazoles obtained by microwave-green synthesis

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dc.authoridDalmaz, Aslihan/0000-0002-1691-2616en_US
dc.authorscopusid58547440500en_US
dc.authorscopusid57201291096en_US
dc.authorscopusid6603031753en_US
dc.authorscopusid25229718700en_US
dc.authorscopusid56156721800en_US
dc.contributor.authorOzdincer, Mesut
dc.contributor.authorDalmaz, Aslihan
dc.contributor.authorDurmus, Sefa
dc.contributor.authorDülger, Görkem
dc.contributor.authorKiliccioglu, Ilker
dc.date.accessioned2024-08-23T16:03:56Z
dc.date.available2024-08-23T16:03:56Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBenzothiazole compounds are known as an important bicyclic ring system with multiple applications. These compounds have a wide range of biological activities, including anticancer, antimicrobial, anti-inflammatory and antiviral activities. In this study, benzothiazole compounds were synthesized and their various biological activities were examined. The synthesized benzothiazoles were evaluated for their antimicrobial properties against various bacterial and fungal strains. The compound 6e is most active ligand in the series against bacteria and fungi as compared to standard antibiotics. Especially, this compound significant effect against Staphylococcus aureus (32.00 +/- 1.73 mm). These compounds exhibited potent anticancer activity against gastrointestinal cancer cells, demonstrating their potential as therapeutic agents. The lowest antiproliferative response after administration of the compounds was observed in HCT116 cells, while the most effective antiproliferative response was observed in AGS cells (> 10 mu g/mL). In all cell lines, 40 and 100 mu g/mL application values of the selected compounds showed significant increases in the expression of caspase-3, 8 and 9. We also utilized a computational docking approach to investigate the interaction of these benzothiazoles with VEGFR-2 kinase. Our docking studies showed that compounds 6a and 6d may be promising therapeutic agents against gastrointestinal system cancers due to their ability to bind to VEGFR-2 kinase.en_US
dc.description.sponsorshipDuzce University Scientific Research Fund [2012.05]en_US
dc.description.sponsorshipAcknowledgements This study was financially supported by Duzce University Scientific Research Fund (Project No: 2012.05.HD.051) . The authors declare that they have no conflict of interest.en_US
dc.identifier.doi10.1590/0001-3765202420230423
dc.identifier.issn0001-3765
dc.identifier.issn1678-2690
dc.identifier.pmid39016356en_US
dc.identifier.scopus2-s2.0-85199015882en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1590/0001-3765202420230423
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13989
dc.identifier.volume96en_US
dc.identifier.wosWOS:001272212200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcad Brasileira De Cienciasen_US
dc.relation.ispartofAnais Da Academia Brasileira De Cienciasen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzothiazoleen_US
dc.subjectMolecular evolutionen_US
dc.subjectDocking studiesen_US
dc.subjectAntimicrobialen_US
dc.subjectAntipro- liferativeen_US
dc.subjectGastrointestinal cancer cellsen_US
dc.subjectDerivativesen_US
dc.subjectCanceren_US
dc.subjectChemistryen_US
dc.subjectBasesen_US
dc.titleBiological evaluation of benzothiazoles obtained by microwave-green synthesisen_US
dc.typeArticleen_US

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