Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors

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dc.contributor.authorSönmez, Fatih
dc.contributor.authorSevmezler, Sedat
dc.contributor.authorAtahan, Alparslan
dc.contributor.authorCeylan, Mustafa
dc.contributor.authorDemir, Dudu
dc.contributor.authorGencer, Nahit
dc.contributor.authorKüçükislamoğlu, Mustafa
dc.date.accessioned2020-05-01T12:14:52Z
dc.date.available2020-05-01T12:14:52Z
dc.date.issued2011
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Kimya Bölümüen_US
dc.descriptionGencer, Nahit/0000-0001-7092-8857en_US
dc.descriptionWOS: 000297150600048en_US
dc.descriptionPubMed: 22055203en_US
dc.description.abstractA newly series of 4-(phenylurenyl) chalcone (4a-j) and 4'-(phenylurenyl/thiourenyl)chalcone (9a-l) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana on an affinity gel comprised of Sepharose 4B-L-tyrosine-p-aminobenzoic acid. The result showed that 4a-j inhibited the PPO enzyme activity. Conversely, 9a-h and 9i-l showed activator effect on tyrosinase enzyme activity. (C) 2011 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.bmcl.2011.09.130en_US
dc.identifier.endpage7482en_US
dc.identifier.issn0960-894X
dc.identifier.issn1464-3405
dc.identifier.issue24en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage7479en_US
dc.identifier.urihttps://doi.org/10.1016/j.bmcl.2011.09.130
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6366
dc.identifier.volume21en_US
dc.identifier.wosWOS:000297150600048en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofBioorganic & Medicinal Chemistry Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChalconesen_US
dc.subjectTyrosinase inhibitorsen_US
dc.titleEvaluation of new chalcone derivatives as polyphenol oxidase inhibitorsen_US
dc.typeArticleen_US

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