Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors
Yükleniyor...
Dosyalar
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A newly series of 4-(phenylurenyl) chalcone (4a-j) and 4'-(phenylurenyl/thiourenyl)chalcone (9a-l) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana on an affinity gel comprised of Sepharose 4B-L-tyrosine-p-aminobenzoic acid. The result showed that 4a-j inhibited the PPO enzyme activity. Conversely, 9a-h and 9i-l showed activator effect on tyrosinase enzyme activity. (C) 2011 Elsevier Ltd. All rights reserved.
Açıklama
Gencer, Nahit/0000-0001-7092-8857
WOS: 000297150600048
PubMed: 22055203
WOS: 000297150600048
PubMed: 22055203
Anahtar Kelimeler
Chalcones, Tyrosinase inhibitors
Kaynak
Bioorganic & Medicinal Chemistry Letters
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
21
Sayı
24
