The effects of N-acetylcysteine and vitamin C on liver and pulmonary tissue damage in rats following bile duct ligation

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dc.contributor.authorÖztürk, Hayrettin
dc.contributor.authorTerzi, Elçin H.
dc.contributor.authorÖztürk, Hülya
dc.contributor.authorKükner, Aysel
dc.date.accessioned2020-04-30T23:33:28Z
dc.date.available2020-04-30T23:33:28Z
dc.date.issued2008
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000262345300008en_US
dc.descriptionPubMed: 18998004en_US
dc.description.abstractObjective: To evaluate the effects of N-acetylcysteine (NAC) and vitamin C on pulmonary histological alterations in bile duct-ligated (BDL) rats. Methods: The current study was conducted in the Department of Pediatric Surgery, Medical School of Abant Izzet Baysal University Bolu, Turkey between May 2007 and July 2007. Thirty-five males Sprague-Dawley rats, weighing 210-240 grams, were used. Group I rats (n=7) underwent only laparotomy. Group 2 rats (n=7) were subjected to BDL. Group 3 rats (n=7) were subjected to BDL and given vitamin C. Group 4 rats (n=7) were subjected to BDL and given NAC. Group 5 rats (n=7) were subjected to BDL and received NAC plus vitamin C. At the end of the 3 week period, biochemical and histological evaluations were processed. Results: Total bilirubin values were decreased in group 5 compared to group 2, 3, and 4. Group 2 showed massive interstitial infiltration with inflammatory cells. Interstitial edema, focal cuboidal metaplasias of alveolar lining cells, and severely damaged pulmonary architecture were noted. Treatment of rats with NAC and vitamin C produced a significant reduction in the histopathological score compared to groups 2, 3, and 4. Conclusions: The combination of NAC and vitamin C reduced lung histological alterations in BDL rats with afforded by each drug individually.en_US
dc.identifier.endpage1584en_US
dc.identifier.issn0379-5284
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1580en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4976
dc.identifier.volume29en_US
dc.identifier.wosWOS:000262345300008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSaudi Med Jen_US
dc.relation.ispartofSaudi Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleThe effects of N-acetylcysteine and vitamin C on liver and pulmonary tissue damage in rats following bile duct ligationen_US
dc.typeArticleen_US

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