Adherence to Growth Hormone Treatment in Children During the COVID-19 Pandemic

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dc.authoridKILCI, FATIH/0000-0003-4040-7908
dc.authoridcamtosun, emine/0000-0002-8144-4409;
dc.contributor.authorEren, Erdal
dc.contributor.authorCetinkaya, Semra
dc.contributor.authorOngen, Yasemin Denkboy
dc.contributor.authorTercan, Ummahan
dc.contributor.authorDarcan, Sukran
dc.contributor.authorTuran, Hande
dc.contributor.authorAydin, Murat
dc.date.accessioned2025-10-11T20:47:39Z
dc.date.available2025-10-11T20:47:39Z
dc.date.issued2024
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjective: Treatment adherence is crucial for the success of growth hormone (GH) therapy. Reported non-adherence rates in GH treatment have varied widely. Several factors may have an impact on adherence. Apart from these factors, the global impact of the Coronavirus disease-2019 (COVID-19) pandemic, including problems with hospital admission and routine follow-up of patients using GH treatment, may have additionally affected the adherence rate. The primary objective of this study was to investigate adherence to treatment in patients receiving GH. In addition, potential problems with GH treatment during the pandemic were investigated. Methods: This was a multicenter survey study that was sent to pediatric endocrinologists during the pandemic period (June-December 2021). Patient data, diagnosis, history of pituitary surgery, current GH doses, duration of GH therapy, the person administering therapy (either parent/patient), duration of missed doses, reasons for missed doses, as well as problems associated with GH therapy, missed dose data and the causes in the recent year (after the onset of the pandemic) were questioned. Treatment adherence was categorized based on missed dose rates over the past month (0 to 5%, full adherence; 5.1 to 10% moderate adherence; >10% non-adherence). Results: The study cohort consisted of 427 cases (56.2% male) from thirteen centers. Median age of diagnosis was 8.13 (0.13-16) years. Treatment indications were isolated GH deficiency (61.4%), multiple pituitary hormone deficiency (14%), Turner syndrome (7.5%), idiopathic GH deficiency (7.5%), small for gestational age (2.8%), and others (6.8%). GH therapy was administered by parents in 70% and by patients in 30%. Mean daily dose was 32.3 big/kg, the annual growth rate was 1.15 standard deviation score (minimum-2.74, maximum 9.3). Overall GH adherence rate was good in 70.3%, moderate in 14.7%, and poor in 15% of the patients. The reasons for non-adherence were mainly due to forgetfulness, being tired, inability to access medication, and/or pen problems. It was noteworthy that there was a negative effect on adherence during the COVID-19 pandemic reported by 22% of patients and the main reasons given were problems obtaining an appointment, taking the medication, and anxiety about going to hospital. There was no difference between genders in the adherence rate. Non-adherence to GH treatment decreased significantly when the patient: administered the treatment; was older; had longer duration of treatment; and during the pandemic. There was a non-significant decrease in annual growth rate as non-adherence rate increased. Conclusion: During the COVID-19 pandemic, the poor adherence rate was 15%, and duration of GH therapy and older age were important factors. There was a negative effect on adherence during the pandemic period.en_US
dc.identifier.doi10.4274/jcrpe.galenos.2024.2023-10-8
dc.identifier.endpage263en_US
dc.identifier.issn1308-5727
dc.identifier.issn1308-5735
dc.identifier.issue3en_US
dc.identifier.pmid38488049en_US
dc.identifier.scopus2-s2.0-85203418854en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage256en_US
dc.identifier.trdizinid1281324en_US
dc.identifier.urihttps://doi.org/10.4274/jcrpe.galenos.2024.2023-10-8
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1281324
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21506
dc.identifier.volume16en_US
dc.identifier.wosWOS:001309453800002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofJournal of Clinical Research in Pediatric Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectChildrenen_US
dc.subjectgrowth hormoneen_US
dc.subjectadherenceen_US
dc.subjectCOVID-19en_US
dc.subjectpandemicen_US
dc.titleAdherence to Growth Hormone Treatment in Children During the COVID-19 Pandemicen_US
dc.typeArticleen_US

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