Misoprostol-Induced Modification of the Notch Signaling Pathway in the Human Cervix

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dc.contributor.authorAvcı, Sema
dc.contributor.authorŞimşek, Mehmet
dc.contributor.authorSoylu, Hakan
dc.contributor.authorÜstünel, İsmail
dc.date.accessioned2020-04-30T23:19:14Z
dc.date.available2020-04-30T23:19:14Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000475782200005en_US
dc.descriptionPubMed: 30278829en_US
dc.description.abstractThe complex and multifactorial mechanisms that initiate and sustain the early labor process in the human uterus and cervix are still not well defined. Cervical maturation or ripening is likely to play a key role in preparing for birth. Prostaglandins have many different functions, including the regulation of uterine contractility and structure during pregnancy. The prostaglandin E1 analogue misoprostol is frequently used as a uterotonic and cervical ripening agent. Notch is a transmembrane receptor family responsible for basic functions such as cell survival, cell-cell communication, and differentiation and decidualization in pregnancy. However, our understanding of the effect of Notch signaling on the cervical ripening process is limited. This study was conducted in 20 pregnant women aged at 12 to 20 weeks of gestation undergoing medical abortion for fetal or maternal indications. True-Cut needle biopsies were taken from the anterior cervix 4 hours after oral ingestion of 200-mu g misoprostol or before the ingestion of misoprostol in the control group. Cervical expression of Notch receptors and ligands changed during the early phase of prostaglandin-induced preterm labor. Four hours after the administration of misoprostol, it was seen that N1 expression increased in muscle, while DLL1 and J2 expression increased in blood vessels, and N4 expression increased in macrophages. Knowing the mechanisms that initiate preterm birth is the most important step in planning the treatments and actions to prevent premature birth. As a signal that affects and perhaps directs preterm labor, Notch is prone to be an important actor in this process.en_US
dc.description.sponsorshipScientific and Technical Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [215S942]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Scientific and Technical Research Council of Turkey (TUBITAK) with Grant No. 215S942.en_US
dc.identifier.doi10.1177/1933719118799208en_US
dc.identifier.endpage917en_US
dc.identifier.issn1933-7191
dc.identifier.issn1933-7205
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage909en_US
dc.identifier.urihttps://doi.org/10.1177/1933719118799208
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3697
dc.identifier.volume26en_US
dc.identifier.wosWOS:000475782200005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofReproductive Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmisoprostolen_US
dc.subjectpreterm laboren_US
dc.subjectnotch signalingen_US
dc.subjecthuman cervixen_US
dc.titleMisoprostol-Induced Modification of the Notch Signaling Pathway in the Human Cervixen_US
dc.typeArticleen_US

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