Biomechanical and histological effects of intra-articular hyaluronic acid on anterior cruciate ligament in rats

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dc.contributor.authorYücel, İstemi
dc.contributor.authorKaraca, Erkut
dc.contributor.authorÖzturan, Kutay
dc.contributor.authorYıldırım, Ümran
dc.contributor.authorDuman, Seçkin
dc.contributor.authorDeğirmenci, Erdem
dc.date.accessioned2020-04-30T22:40:16Z
dc.date.available2020-04-30T22:40:16Z
dc.date.issued2009
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000268430600006en_US
dc.descriptionPubMed: 19464776en_US
dc.description.abstractBackground: The histologic and biomechanical effects of intra-articular hyaluronic acid on the anterior cruciate ligaments of rats were investigated. Methods: Thirty rats were divided into three groups, i.e., the hyaluronic acid group, saline group, and control group. The hyaluronic acid and saline groups received a total of four intra-articular injections, whereas no injection was administered to the control group. The hyaluronic acid group was injected with 50 mu g (0.05 cc) hyaluronic acid, and the saline group was injected with 50 mu l (0.05 cc) of 0.9% sodium chloride solution. All of the rats were sacrificed on day 29 and the femur-anterior cruciate ligament-tibia complexes from the right knees were prepared, tested mechanically, and evaluated histologically. Findings: The mode of failure involved the midsubstance of the anterior cruciate ligament in all the specimens. There were no statistically significant differences in the stiffness and ultimate load to failure values between the three groups (P > 0.05). The energy to failure values were evaluated and there was no statistically significant difference between the groups (P = 0.064, chi-square = 3.43). In the histologic analyses, there was a significant difference in the hyalinization values between the hyaluronic acid and saline groups (P = 0.029) and between the hyaluronic acid group and control groups (P = 0.029). Interpretation: The present study shows that intra-articularly delivered hyaluronic acid has no statistically significant effect on the tensile strength of the rat anterior cruciate ligament. Although hyalinization was increased, no difference was found on the other markers for degenerative changes. We conclude that intra-articular hyaluronic acid injections can be performed safely, although the use of a precise injection technique is recommended. (C) 2009 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.clinbiomech.2009.04.011en_US
dc.identifier.endpage576en_US
dc.identifier.issn0268-0033
dc.identifier.issn1879-1271
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage571en_US
dc.identifier.urihttps://doi.org/10.1016/j.clinbiomech.2009.04.011
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2943
dc.identifier.volume24en_US
dc.identifier.wosWOS:000268430600006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofClinical Biomechanicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRaten_US
dc.subjectHyaluronic aciden_US
dc.subjectAnterior cruciate ligamenten_US
dc.subjectIntra-articular injectionen_US
dc.subjectTensile strengthen_US
dc.titleBiomechanical and histological effects of intra-articular hyaluronic acid on anterior cruciate ligament in ratsen_US
dc.typeArticleen_US

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