Chondroprotective effect of Nigella sativa oil in the early stages of osteoarthritis: an experimental study in rabbits

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dc.contributor.authorTurhan, Yalçın
dc.contributor.authorArıcan, Mehmet
dc.contributor.authorKaraduman, Zekeriya Okan
dc.contributor.authorTurhal, Ozan
dc.contributor.authorGamsızkan, Mehmet
dc.contributor.authorAydın, Davut
dc.contributor.authorÖzkan, Korhan
dc.date.accessioned2020-04-30T22:40:47Z
dc.date.available2020-04-30T22:40:47Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionkaraduman, zekeriya okan/0000-0002-6719-3666;en_US
dc.descriptionWOS: 000484034200015en_US
dc.descriptionPubMed: 31475944en_US
dc.description.abstractPurpose: Nigella sativa oil possesses a well-known ability to protect certain organs from oxidative, neoplastic, and inflammatory damage. This study investigated the potential chondroprotective effects of intraarticular injections of Nigella sativa oil in a rabbit osteoarthritis model. Methods: Osteoarthritis models were created by performing anterior cruciate ligament transections in 20 New Zealand rabbits. Rabbits were randomly divided into two groups of 10 and given intraarticular injections in their right knees weekly for 5 weeks, beginning in the third week post-operation. Injections given to the first group contained whole Nigella sativa oil, whereas the second group was injected with a saline solution. Knee joints were harvested 8 weeks after surgery. Knee joint surfaces were examined macroscopically, and medial femoral condyle sections were examined microscopically. Results: There was a statistically significant difference in the macroscopic grading results of the groups, with the Nigella sativa group having better results (p=0.001). The Nigella sativa group also received significantly better total Osteoarthritis Research Society International (OARSI) scores (p=0.035). Conclusions: Intraarticular administration of Nigella sativa oil has the potential to protect cartilage from degeneration in the early stages of osteoarthritis.en_US
dc.description.sponsorshipScientific Research Projects Unit of Duzce University, Duzce, TurkeyDuzce University [2017.4.2.667]en_US
dc.description.sponsorshipThis research was supported by grants from the Scientific Research Projects Unit of Duzce University, Duzce, Turkey (2017.4.2.667). The authors declare no conflict of interest.en_US
dc.identifier.endpage369en_US
dc.identifier.issn1108-7161
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage362en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3058
dc.identifier.volume19en_US
dc.identifier.wosWOS:000484034200015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherJmnien_US
dc.relation.ispartofJournal Of Musculoskeletal & Neuronal Interactionsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNigella sativa oilen_US
dc.subjectOsteoarthritisen_US
dc.subjectIntraarticularen_US
dc.subjectACLTen_US
dc.subjectRabbiten_US
dc.titleChondroprotective effect of Nigella sativa oil in the early stages of osteoarthritis: an experimental study in rabbitsen_US
dc.typeArticleen_US

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