The effect of topical ciprofloxacin and steroid-containing ear drops for chronic suppurative otitis media on the internal ear

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dc.contributor.authorKapusuz, Zeliha
dc.contributor.authorKeleş, Erol
dc.contributor.authorAlpay, Hayrettin Cengiz
dc.contributor.authorKarlıdağ, Turgut
dc.contributor.authorKaygusuz, İrfan
dc.contributor.authorUzunlar, Ali Kemal
dc.contributor.authorYalçın, Şinasi
dc.date.accessioned2020-04-30T23:33:13Z
dc.date.available2020-04-30T23:33:13Z
dc.date.issued2010
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionKARLIDAG, turgut/0000-0003-2748-7309; Kaygusuz, Irfan/0000-0002-5237-2362; Keles, Erol/0000-0003-4443-6714; YALCIN, SINASI/0000-0002-6528-9234en_US
dc.descriptionWOS: 000272074500006en_US
dc.descriptionPubMed: 19554344en_US
dc.description.abstractAim of the study is to evaluate the effects of topical ciprofloxacin and prednisolone-containing ear drops for chronic suppurative otitis media on hearing threshold, cochlear reserve and cochlea morphology in healthy subjects and to determine the proper drug dose. Sixty-eight guinea pigs, all of which had healthy hearing, were used for the study. The first group (n = 30) was administered ciprofloxacin three times a day, the second group (n = 30) was administered prednisolone three times a day and the third group (n = 8) was administered sterile distilled water three times a day. The therapies lasted for 7 days and were administered intratympanically. The first group and second group were divided into three sub-groups of ten subjects. The first sub-group (n = 10) was administered an equivalent dose per kilogram as in humans, the second sub-group (n = 10) was administered one-third of the human-equivalent dose and the third sub-group (n = 10) was administered tenfold the human-equivalent dose. All subjects underwent brainstem evoked response audiometry (BERA) and distortion product otoacoustic emission (DPOAE) testing on the seventh and twenty-first days following the therapy. Following the tests, two subjects from each group were decapitated and examined under electron microscope. BERA and DPOAE testing results of the sub-group (n = 10) which was administered tenfold the human-equivalent dose were significantly different from the control group and other groups (P < 0.05). According to electron microscopic examination of the cochlea, the group which was administered a tenfold human-equivalent dose of intratympanic ciprofloxacin and prednisolone showed atrophy in cells and degenerations in cilia. This case was statistically significant when compared with the control group and other groups (P < 0.05). Ciprofloxacin and prednisolone applied at a human-equivalent dose per kilogram did not affect the hearing and cochlear histology of subjects.en_US
dc.identifier.doi10.1007/s00405-009-1012-xen_US
dc.identifier.endpage41en_US
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage35en_US
dc.identifier.urihttps://doi.org/10.1007/s00405-009-1012-x
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4923
dc.identifier.volume267en_US
dc.identifier.wosWOS:000272074500006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Archives Of Oto-Rhino-Laryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCiprofloxacinen_US
dc.subjectPrednisoloneen_US
dc.subjectOtotoxicityen_US
dc.titleThe effect of topical ciprofloxacin and steroid-containing ear drops for chronic suppurative otitis media on the internal earen_US
dc.typeArticleen_US

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