Does amikacin treatment cause subclinical hearing loss in patients with cystic fibrosis?

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dc.contributor.authorSolmaz, Fevzi
dc.contributor.authorGündoğdu, Ercan
dc.contributor.authorAkduman, Davut
dc.contributor.authorHaksever, Mehmet
dc.contributor.authorDikici, Oğuzhan
dc.contributor.authorÜnal, Fatih
dc.date.accessioned2020-05-01T09:11:28Z
dc.date.available2020-05-01T09:11:28Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000399044300046en_US
dc.descriptionPubMed: 28959562en_US
dc.description.abstractIntroduction: Aminoglycosides (AGs) have been widely used for potential life-threatening bacterial infections. Although AGs are well known for their ototoxic side effects, some AGs such as amikacin are considered less harmful to auditory functions; thus, auditory monitoring is mostly neglected during treatment with these drugs. Objective: To reflect the potential auditory hazards of repeated amikacin use on the patients with cystic fibrosis (CF). Method: 32CF patients with prior exposure to at least 3 courses of amikacin (the CF group) and 35 non CF patients visiting the outpatient clinic with any complaint other than hearing loss and no history of treatment with any AG( the control, or C group) were compared with pure-tone audiometry(PTA). The diagnosis of CF was made by Nanoduck sweat test. Results: The average age of the participants were 8.25 +/- 2.76 years in the CF group and 8.58 +/- 2.00 years in the C group (ranging from 5 to 13 years). 29 (43.28%) of the cases were female and 38 (56.71%) were male. Clinical SNHL(sensorineural hearing loss) was detected in 4 of the 32 subjects in the CF group. None of the subjects in the C group exhibited clinical SNHL. There was no statistically significant difference between the groups with regard to presence or absence of clinical SNHL (p > 0.05). However, hearing levels of the CF group were around 20 dB(decibel) HL(hearing loss), whereas hearing levels of the C group were around 5 dB. This difference was statistically significant for the pure tone averages of both all frequencies and speech frequencies (p < 0.05). Conclusion: Repetitive exposure to AGs can cause permanent, although mild, sensorineural hearing loss. For prevention, hearing status of the patient should be closely monitored and treatment of choice should be precisely tailored according to the audiological evaluation. This is especially important in patients with CF who frequently experience medical conditions necessitating AGs use. (C) 2016 Published by Elsevier Ireland Ltd.en_US
dc.identifier.doi10.1016/j.toxrep.2016.03.010en_US
dc.identifier.endpage404en_US
dc.identifier.issn2214-7500
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage401en_US
dc.identifier.urihttps://doi.org/10.1016/j.toxrep.2016.03.010
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5608
dc.identifier.volume3en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofToxicology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAminoglycosidesen_US
dc.subjectAmikacinen_US
dc.subjectCystic Fibrosisen_US
dc.subjectOtotoxicityen_US
dc.subjectHearing lossen_US
dc.titleDoes amikacin treatment cause subclinical hearing loss in patients with cystic fibrosis?en_US
dc.typeArticleen_US

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