Morphine modulates microvascular leakage dose-dependently in the airway of ovalbumin-sensitized rats

Basit Öğe Kaydı
dc.contributor.authorArslan, Seyfullah Oktay
dc.date.accessioned2020-04-30T23:19:20Z
dc.date.available2020-04-30T23:19:20Z
dc.date.issued2010
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionARSLAN, SEYFULLAH OKTAY/0000-0001-9328-9373en_US
dc.descriptionWOS: 000278446800016en_US
dc.description.abstractAim: To investigate the effect of morphine on ovalbumin-evoked airway microvascular leakage in sensitized rats. Materials and methods: Rats were sensitized on clays 0, 14, and 21 with ovalbumin. Intravenous ovalbumin (2 mg/kg) or capsaicin (50 mu g/kg) increased the extravasation of Evans blue dye in trachea, bronchi, and intra-pulmonary tissues of sensitized rats. Results: Morphine (1-10 mg/kg) inhibited ovalbumin-evoked increase in microvascular plasma leakage in a dose-dependent manner; however, it had no significant effect at the doses of 0.1 or 30 mg/kg. In addition, morphine, at the closes of 1-30 mg/kg, abolished microvascular leakage increased by capsaicin. The inhibition caused by morphine was blocked by the peripheral opioid receptor antagonist, naloxone methiodide, in ovalbumin or capsaicin series. Morphine or naloxone methiodide has alone no effect on plasma leakage. Conclusion: These results conclude that morphine inhibits microvascular leakage, maybe mediated by neurogenic inflammation in sensitized rats, via peripheral opioid receptors.en_US
dc.description.sponsorshipOffice of Research and Sponsored Programs, Zonguldak Karaelmas UniversityBulent Ecevit Universityen_US
dc.description.sponsorshipThe author wish to thank Dr F. Bayiroglu for many helpful discussions and for the critical review of the manuscript. This work was supported by intramural funding of the Office of Research and Sponsored Programs, Zonguldak Karaelmas University. Preliminary results of the present study were presented at the 18<SUP>th</SUP> National Pharmacology Congress of Turkish Pharmacological Society, 28 September-1 October 2005, Izmir, Turkiye.en_US
dc.identifier.doi10.3906/sag-0812-11en_US
dc.identifier.endpage286en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage279en_US
dc.identifier.urihttps://doi.org/10.3906/sag-0812-11
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3726
dc.identifier.volume40en_US
dc.identifier.wosWOS:000278446800016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMicrovascular leakageen_US
dc.subjectairwayen_US
dc.subjectsensitizationen_US
dc.subjectovalbuminen_US
dc.subjectcapsaicinen_US
dc.subjectmorphineen_US
dc.subjectnaloxone methiodideen_US
dc.subjectraten_US
dc.titleMorphine modulates microvascular leakage dose-dependently in the airway of ovalbumin-sensitized ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
3726.pdf
Boyut:
234.32 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu