Morphine modulates microvascular leakage dose-dependently in the airway of ovalbumin-sensitized rats
Loading...
Files
Date
2010
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Tubitak Scientific & Technical Research Council Turkey
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
Aim: To investigate the effect of morphine on ovalbumin-evoked airway microvascular leakage in sensitized rats. Materials and methods: Rats were sensitized on clays 0, 14, and 21 with ovalbumin. Intravenous ovalbumin (2 mg/kg) or capsaicin (50 mu g/kg) increased the extravasation of Evans blue dye in trachea, bronchi, and intra-pulmonary tissues of sensitized rats. Results: Morphine (1-10 mg/kg) inhibited ovalbumin-evoked increase in microvascular plasma leakage in a dose-dependent manner; however, it had no significant effect at the doses of 0.1 or 30 mg/kg. In addition, morphine, at the closes of 1-30 mg/kg, abolished microvascular leakage increased by capsaicin. The inhibition caused by morphine was blocked by the peripheral opioid receptor antagonist, naloxone methiodide, in ovalbumin or capsaicin series. Morphine or naloxone methiodide has alone no effect on plasma leakage. Conclusion: These results conclude that morphine inhibits microvascular leakage, maybe mediated by neurogenic inflammation in sensitized rats, via peripheral opioid receptors.
Description
ARSLAN, SEYFULLAH OKTAY/0000-0001-9328-9373
WOS: 000278446800016
WOS: 000278446800016
Keywords
Microvascular leakage, airway, sensitization, ovalbumin, capsaicin, morphine, naloxone methiodide, rat
Journal or Series
Turkish Journal Of Medical Sciences
WoS Q Value
Q4
Scopus Q Value
Q3
Volume
40
Issue
2
