Investigation of the anticancer effects of some plant seed oils with medicinal uses

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dc.authorscopusid57216300593en_US
dc.authorscopusid25229718700en_US
dc.authorscopusid56497935400en_US
dc.authorwosidKURMAN, Yener/KFS-5599-2024en_US
dc.contributor.authorKurman, Yener
dc.contributor.authorDuelger, Goerkem
dc.contributor.authorPasin, Ozge
dc.date.accessioned2024-08-23T16:03:40Z
dc.date.available2024-08-23T16:03:40Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractCancer is an important health problem and responsible for a significant number of deaths worldwide. Chemotherapy resistance and related side effects prevent cancer treatment from reaching the desired level. In this study, we aimed to investigate the anti-cancer properties of Carthamus tinctorius, Salvia hispanica and Linum usitatissimum seed oils on hepatocellular (HepG2), colorectal (HCT-116) and gastric carcinoma (AGS) cell lines. Human umbilical vein endothelial cells (HUVECs) were used as control cell group. Cell viability of HepG2, HCT-116, AGS and HUVECs was determined by MTT method after treatment with various concentrations of Carthamus tinctorius, Salvia hispanica and Linum usitatissimum. Colorimetric elisa kit was used for quantitative determination of caspase-3 activation. Anti -migratory effect of Carthamus tinctorius and Salvia hispanica were investigated by wound healing assay. Carthamus tinctorius, Salvia hispanica and Linum usitatissimum seed oils significantly inhibited the proliferation of cancer cells. There was an insignificant decrease in the viability of HUVEC cells after seed oils treatments. Migration of HepG2 and AGS cells significantly suppressed by treatment of Salvia hispanica and Carthamus tinctorius respectively. Salvia hispanica and Carthamus tinctorius significantly increased caspase-3 activation in cancer cells. Our results showed that Carthamus tinctorius, Salvia hispanica and Linum usitatissimum exhibited a selective cytotoxicity against HepG2, HCT-116 and AGS cells without damaging normal cells.en_US
dc.identifier.doi10.29228/jrp.444
dc.identifier.endpage1604en_US
dc.identifier.issn2630-6344
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85165877201en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1594en_US
dc.identifier.trdizinid1190005en_US
dc.identifier.urihttps://doi.org/10.29228/jrp.444
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1190005
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13862
dc.identifier.volume27en_US
dc.identifier.wosWOS:001037073200014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMarmara Univen_US
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCarthamus tinctoriusen_US
dc.subjectSalvia hispanicaen_US
dc.subjectLinum usitatissimumen_US
dc.subjectanticanceren_US
dc.subjectmigrationen_US
dc.subjectcaspase-3en_US
dc.subjectCarthamus-Tinctoriusen_US
dc.subjectHydroxysafflor Yellowen_US
dc.subjectFlaxseed Oilen_US
dc.subjectSaffloweren_US
dc.subjectPhytochemistryen_US
dc.subjectAngiogenesisen_US
dc.subjectPharmacologyen_US
dc.subjectInhibitionen_US
dc.subjectMigrationen_US
dc.subjectTumorsen_US
dc.titleInvestigation of the anticancer effects of some plant seed oils with medicinal usesen_US
dc.typeArticleen_US

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