Effect of Nifedipine on Hippocampal Neuron Number in Penicillin-Induced Epileptic Rats

Basit Öğe Kaydı
dc.contributor.authorYılmaz, İsmail
dc.contributor.authorAkdoğan, Ilgaz
dc.contributor.authorKaya, Ertuğrul
dc.contributor.authorYonguç, Gökşin Nilüfer
dc.date.accessioned2020-05-01T09:11:44Z
dc.date.available2020-05-01T09:11:44Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionKaya, Ertugrul/0000-0003-0081-682Xen_US
dc.descriptionWOS: 000334560800014en_US
dc.descriptionPubMed: 24831366en_US
dc.description.abstractAIM: Epileptic seizures lead to neuronal loss in the hippocampus. Experimental epilepsy can be induced by direct application of various chemicals to cerebral cortex. Nifedipine is an L-type voltage-dependent calcium channel blocker. In spite of several studies that show the seizure-suppressing effects of nifedipine, it has been shown that nifedipine does not suppress but conversely increases epileptic seizures. Similarly, contradictory effects of nifedipine have been reported, such as neuroprotection, failed neuroprotection and neurotoxicity. We therefore aimed to investigate the effect of nifedipine on hippocampal neuronal loss in penicillin induced epileptic rats in this study. MATERIAL and METHODS: The effect of nifedipine on total hippocampal neuron number was estimated by using the optical fractionator method (an unbiased stereological method) in penicillin-G induced epileptic rats. RESULTS:The total number of hippocampal neurons in the control group was 183687 +/- 3184. In the penicillin-induced group, the total neuron number significantly decreased to 146318 +/- 3042 compared to the control group. In the nifedipine group, the neuron number significantly decreased to 128873 +/- 1157 compared to both control and penicillin-induced groups. CONCLUSION: Nifedipine increased neuronal loss and did not suppress epileptic seizures in penicillin-induced epileptic rats. Nifedipine could not protect against hippocampal neuronal loss in penicillin-induced epileptic rats.en_US
dc.identifier.doi10.5137/1019-5149.JTN.8428-13.2en_US
dc.identifier.endpage240en_US
dc.identifier.issn1019-5149
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage234en_US
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.8428-13.2
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5742
dc.identifier.volume24en_US
dc.identifier.wosWOS:000334560800014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Socen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPenicillin epilepsy modelen_US
dc.subjectNifedipineen_US
dc.subjectHippocampusen_US
dc.subjectNeuron numberen_US
dc.subjectThe optical fractionator methoden_US
dc.subjectRaten_US
dc.subjectEpilepsyen_US
dc.subjectSeizureen_US
dc.titleEffect of Nifedipine on Hippocampal Neuron Number in Penicillin-Induced Epileptic Ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
5742.pdf
Boyut:
232.82 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu