Anti-edematous, anti-inflammatory and neuroprotective effect of etanercept in acute stage in experimental head injury

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dc.contributor.authorAykanat, Ömer
dc.contributor.authorKarakoyun, Durmuş Oğuz
dc.contributor.authorTürkoğlu, Mehmet Erhan
dc.contributor.authorDinç, Cem
dc.date.accessioned2020-04-30T22:39:28Z
dc.date.available2020-04-30T22:39:28Z
dc.date.issued2017
dc.departmentDÜ, Tıp Fakültesien_US
dc.descriptionWOS: 000403589400001en_US
dc.descriptionPubMed: 28530785en_US
dc.description.abstractBACKGROUND: To study the anti-edematous, anti-inflammatory, and neuroprotective effect of etanercept in the model of experimental head injury. METHODS: In this study, 40 male-adult Spraque-Dawley rats, with weight ranging from 250g to 300g, were used. The rats are divided into groups as control; non-penetrating trauma; trauma + NS; post-traumatic normal saline; trauma + D; post-traumatic dexamethasone and trauma + E. All medicines were given into peritoneum. After applying trauma and medicine, rats were decapitated in the 24th hour and the samples were studied histopathologically. RESULTS: In the study, a statistically significant difference was observed between the groups of trauma + NS and trauma dexamethasone according to the variables of edema and inflammation, but no difference was observed according to the variables of neuronal damage, astrocytic damage, and glial apoptosis. Moreover, a significant difference was observed between groups of Trauma + NS and trauma+ etanercept and between the groups of trauma + dexamethasone and trauma + etanercept in terms of all variables. CONCLUSION: It was observed that etanercept has anti-edematous, anti-inflammatory, and neuroprotective effect on the rats which experienced traumatic brain injury.en_US
dc.identifier.doi10.5505/tjtes.2016.43692en_US
dc.identifier.endpage180en_US
dc.identifier.issn1306-696X
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage173en_US
dc.identifier.urihttps://doi.org/10.5505/tjtes.2016.43692
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2732
dc.identifier.volume23en_US
dc.identifier.wosWOS:000403589400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal Of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBrain edemaen_US
dc.subjectetanercepten_US
dc.subjecthead injuryen_US
dc.titleAnti-edematous, anti-inflammatory and neuroprotective effect of etanercept in acute stage in experimental head injuryen_US
dc.typeArticleen_US

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