In Vivo Genotoxicity Assessment of Sertraline by Using Alkaline Comet Assay and the Cytokinesis-Block Micronucleus Assay

Basit Öğe Kaydı
dc.contributor.authorBattal, Dilek
dc.contributor.authorAktaş, Ayça
dc.contributor.authorSungur, Mehmet Ali
dc.contributor.authorKadıoğlu, Ela
dc.contributor.authorEker, Ebru Derici
dc.contributor.authorŞahin, Nefise Özlen
dc.contributor.authorSaygi, Şahan
dc.date.accessioned2020-04-30T23:18:28Z
dc.date.available2020-04-30T23:18:28Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionAktas Sukuroglu, Ayca/0000-0003-3069-7905; Battal, Dilek/0000-0003-1935-5330en_US
dc.descriptionWOS: 000325465200008en_US
dc.descriptionPubMed: 23759069en_US
dc.description.abstractSertraline, a leading antidepressant in the selective serotonin reuptake inhibitor (SSRI) group of medicine, is the most frequently prescribed drug. In this study, the alkaline comet assay and the cytokinesis-block micronucleus (CBMN) assay were used to investigate genotoxicity potential of sertraline in the peripheral blood lymphocytes (PBLs) of acute and chronic sertraline-treated Wistar albino rats. Male Wistar albino rats (n=48) were administered low, medium and high doses of sertraline (10, 40, 80mg/kg) for acute and chronic treatment by employing the gavage method to investigate genotoxicity of the administered drug. The data (tail length, tail intensity and tail moment) were analysed and indicated that there was no statistically significant difference between sertraline-treated groups and the negative control group with respect to DNA damage (p>0.05). However, it was observed that acute sertraline administration had caused much more DNA damage in comparison with chronic treatment (p<0.05). According to the data obtained from the CBMN test, an increase in the micronucleus (MN) frequency was detected at chronic and high-dose acute sertraline treatment. Based on the outcome of comet assay, detection of statistically insignificant DNA damage may be due to the fact that sertraline did not cause damage on DNA. Also, increase in frequency of MN in chronic sertraline treatment suggests that chronic sertraline administration might influence some mechanisms of cell division. Therefore, dose adjustment in depressed patients seems significant as it may help prevent further prognosis of the diseases.en_US
dc.description.sponsorshipMersin University, Department of Scientific Research ProjectsMersin University [BAP ECZ F EMB (DB) 2010-5 A]en_US
dc.description.sponsorshipThis work was supported by Mersin University, Department of Scientific Research Projects [Grant number: BAP ECZ F EMB (DB) 2010-5 A].en_US
dc.identifier.doi10.1111/bcpt.12095en_US
dc.identifier.endpage346en_US
dc.identifier.issn1742-7835
dc.identifier.issn1742-7843
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage339en_US
dc.identifier.urihttps://doi.org/10.1111/bcpt.12095
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3333
dc.identifier.volume113en_US
dc.identifier.wosWOS:000325465200008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofBasic & Clinical Pharmacology & Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleIn Vivo Genotoxicity Assessment of Sertraline by Using Alkaline Comet Assay and the Cytokinesis-Block Micronucleus Assayen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
3333.pdf
Boyut:
150.14 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu