Argyrophilic nucleolar organizing region associated protein synthesis for cytologic discrimination of follicular thyroid lesions

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dc.contributor.authorOktay, Murat
dc.contributor.authorEröz, Recep
dc.contributor.authorOktay, N.A.
dc.contributor.authorErdem, Havva
dc.contributor.authorBaşar, Feyza
dc.contributor.authorAkyol, L.
dc.contributor.authorBahadır, Anzel
dc.date.accessioned2020-04-30T22:39:38Z
dc.date.available2020-04-30T22:39:38Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000352110200003en_US
dc.descriptionPubMed: 25420891en_US
dc.description.abstractFine needle aspiration biopsy (FNAB) of the thyroid gland is an important tool for preoperative diagnosis; however, its benefit is limited for follicular lesions. Nucleolar organizer regions (NORs) are ribosomal gene regions that stain with silver (Ag) when they are active. These regions can be used to differentiate neoplastic and non-neoplastic lesions. We used a new AgNOR technique to investigate FNAB of cases diagnosed as follicular adenoma and carcinoma. Fourteen cases of follicular thyroid carcinoma (FTC) and 28 cases of thyroid follicular adenomas (FA) were stained using the silver NOR-associated protein (AgNOR) technique. One hundred nuclei per sample were examined, AgNORs were counted, and the total AgNOR area/nuclear area (TNORa/Na) ratio of each cell was calculated. We found that cases with FTC had significantly higher TNORa/Na than cases of FA. Also, cases with FTC had significantly higher AgNOR counts than cases with FA. AgNOR counting may help discriminate FTC and FA by routine cytopathology before surgery.en_US
dc.identifier.doi10.3109/10520295.2014.976271en_US
dc.identifier.endpage183en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage179en_US
dc.identifier.urihttps://doi.org/10.3109/10520295.2014.976271
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2785
dc.identifier.volume90en_US
dc.identifier.wosWOS:000352110200003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgNORsen_US
dc.subjectcytologyen_US
dc.subjectfollicular lesionsen_US
dc.subjectthyroiden_US
dc.titleArgyrophilic nucleolar organizing region associated protein synthesis for cytologic discrimination of follicular thyroid lesionsen_US
dc.typeArticleen_US

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