Effects of Extremely Low-Frequency Magnetic Field on Caspase Activities and Oxidative Stress Values in Rat Brain

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dc.contributor.authorAkdağ, Mehmet Zülküf
dc.contributor.authorDaşdağ, Süleyman
dc.contributor.authorUlukaya, Engin
dc.contributor.authorUzunlar, Ali Kemal
dc.contributor.authorKurt, Mustafa Ayberk
dc.contributor.authorTaşkın, Abdullah
dc.date.accessioned2020-05-01T09:11:56Z
dc.date.available2020-05-01T09:11:56Z
dc.date.issued2010
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000284382500025en_US
dc.descriptionPubMed: 20177816en_US
dc.description.abstractThis study was aimed to investigate the effect of extremely low-frequency magnetic field (ELF-MF) on apoptosis and oxidative stress values in the brain of rat. Rats were exposed to 100 and 500 mu T ELF-MF, which are the safety standards of public and occupational exposure for 2 h/day for 10 months. Brain tissues were immunohistochemically stained for the active (cleaved) caspase-3 in order to measure the apoptotic index by a semi-quantitative scoring system. In addition, the levels of catalase (CAT), malondialdehyde (MDA), myeloperoxidase (MPO), total antioxidative capacity (TAC), total oxidant status (TOS), and oxidative stress index (OS!) were measured in rat brain. Final score of apoptosis and MPO activity were not significantly different between the groups. CAT activity decreased in both exposure groups (p<0.05), while TAC was found to be lower in ELF 500 group than those in ELF-100 and sham groups (p<0.05). MDA, TOS, and OSI values were found to be higher in ELF-500 group than those in ELF-100 and sham groups (p<0.05). In conclusion, apoptosis was not changed by long-term ELF-MF exposure, while both 100 and 500 mu T ELF-MF exposure induced toxic effect in the rat brain by increasing oxidative stress and diminishing antioxidant defense system.en_US
dc.identifier.doi10.1007/s12011-010-8615-3en_US
dc.identifier.endpage249en_US
dc.identifier.issn0163-4984
dc.identifier.issue01.Maren_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage238en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-010-8615-3
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5821
dc.identifier.volume138en_US
dc.identifier.wosWOS:000284382500025en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExtremely low-frequency magnetic fielden_US
dc.subjectOxidative stressen_US
dc.subjectAntioxidant enzymeen_US
dc.subjectCaspase-3 activitiesen_US
dc.subjectBrainen_US
dc.titleEffects of Extremely Low-Frequency Magnetic Field on Caspase Activities and Oxidative Stress Values in Rat Brainen_US
dc.typeArticleen_US

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