Pituitary hyperplasia mimicking pituitary macroadenoma in two adolescent patients with long-standing primary hypothyroidism: case reports and review of literature

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dc.contributor.authorŞimşek, Enver
dc.contributor.authorŞimşek, Tülay
dc.contributor.authorErdeve, Şenay Savaş
dc.contributor.authorErdoğmuş, Beşir
dc.contributor.authorDöşoğlu, Murat
dc.date.accessioned2020-04-30T23:20:59Z
dc.date.available2020-04-30T23:20:59Z
dc.date.issued2009
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000274692900019en_US
dc.descriptionPubMed: 20196402en_US
dc.description.abstractWe report two cases with primary autoimmune hypothyroidism and an ectopic thyroid gland causing pituitary enlargement mimicking pituitary macroadenoma. One of the cases presented with complaints of headache and short stature and the other case with a complaint of menorrhagia. In both cases, the pituitary mass and symptoms resolved with levothyroxine replacement. Normal menses resumed. However, pituitary dynamic tests revealed persistent growth hormone and gonadotropin deficiency in one case and growth hormone deficiency in the other. To our knowledge, this is the first report in an adolescent of hypogonadotropic hypogonadism, growth hormone deficiency, and menorrhagia associated with pituitary hyperplasia secondary to primary hypothyroidism. The recognition of the association between reversible pituitary hyperplasia and primary hypothyroidism might eliminate unnecessary surgery.en_US
dc.identifier.endpage630en_US
dc.identifier.issn0041-4301
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage624en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4117
dc.identifier.volume51en_US
dc.identifier.wosWOS:000274692900019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish J Pediatricsen_US
dc.relation.ispartofTurkish Journal Of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpituitary macroadenomaen_US
dc.subjectprimary hypothyroidismen_US
dc.subjectpituitary hyperplasiaen_US
dc.titlePituitary hyperplasia mimicking pituitary macroadenoma in two adolescent patients with long-standing primary hypothyroidism: case reports and review of literatureen_US
dc.typeReview Articleen_US

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