Relationship among expression of basic-fibroblast growth factor, MTDH/Astrocyte elevated gene-1, adenomatous polyposis coli, matrix metalloproteinase 9,and COX-2 markers with prognostic factors in prostate carcinomas

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dc.contributor.authorErdem, Havva
dc.contributor.authorYıldırım, Ümran
dc.contributor.authorUzunlar, Ali Kemal
dc.contributor.authorÇam, Kamil
dc.contributor.authorTekin, Ali
dc.contributor.authorKayıkçı, Muhammet Ali
dc.contributor.authorAydın, L.Y.
dc.date.accessioned2020-04-30T23:31:36Z
dc.date.available2020-04-30T23:31:36Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionoktay, murat/0000-0002-0893-4444; Ankarali, Handan Camdeviren/0000-0002-3613-0523en_US
dc.descriptionWOS: 000324263300002en_US
dc.descriptionPubMed: 23974731en_US
dc.description.abstractBackground: The etiopathogenesis of prostate cancer (PC) is still not clear, but hormonal, genetic, and environmental factors are thought to play a role in the tumor pathogenesis. Astrocyte elevated gene-1(AEG-1) as a novel transmembrane protein is predominantly located in the perinuclear region and endoplasmic reticulum. It has been found that AEG-1 upregulation increases the invasive ability of glioma and prostate cancer. Basic fibroblast growth factor (bFGF), matrix metalloproteinase-9 (MMP-9), cyclooxygenases-2 (COX-2), and adenomatous polyposis coli (APC) are very important in tumor progression as well. Materials and Methods: This study included 97 radical prostatectomy specimens. IHC stains for bFGF, MMP-9, COX-2, APC, and AEG-1 were performed on the tissue microarray using standard procedures. For each patient, the age, Gleason score, tumor volume, lymphovascular invasion, lymph node metastasis, surgical margin, and the invasion of vesiculoseminalis areas were assessed. Analyses were performed using the statistical PASW (ver. 18). Results: Statistically significant positive relationships were found MMP-9 and COX-2 (r = 0.242 and P = 0.017), between MMP-9 and APC (r = 0.207 and P = 0.043), and between bFGF and AEG-1 (r = 0.295 and P = 0.004). However, the relationships between age and staining results and tumor volume and staining results were not found to be significant. Although a positive correlation was found between the Gleason score and tumor volume and the Gleason score and age (r = 0.415 and P = 0.0001; r = 0.246 and P = 0.015, respectively), we did not find a statistically significant relationship between other stains and other prognostic parameters (lymphovascular invasion, lymph node metastasis, surgical margin, or vesiculoseminalis invasion). Conclusion: The relationships we found between MMP-9 and COX-2, between MMP-9, and APC and between bFGF and AEG-1 as independent prognostic parameters could be helpful in the development of new therapeutic procedures.en_US
dc.description.sponsorshipDuzce UniversityDuzce Universityen_US
dc.description.sponsorshipThis project is supported by Duzce University Research Funden_US
dc.identifier.doi10.4103/1119-3077.116873en_US
dc.identifier.endpage423en_US
dc.identifier.issn1119-3077
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage418en_US
dc.identifier.urihttps://doi.org/10.4103/1119-3077.116873
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4346
dc.identifier.volume16en_US
dc.identifier.wosWOS:000324263300002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNigerian Journal Of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdenomatous polyposis colien_US
dc.subjectastrocyte elevated gene-1en_US
dc.subjectbasic fibroblast growth factoren_US
dc.subjectcyclooxygenases-2en_US
dc.subjectmatrix metalloproteinase-9en_US
dc.subjectprognostic parametersen_US
dc.subjectprostate adenocarcinomasen_US
dc.titleRelationship among expression of basic-fibroblast growth factor, MTDH/Astrocyte elevated gene-1, adenomatous polyposis coli, matrix metalloproteinase 9,and COX-2 markers with prognostic factors in prostate carcinomasen_US
dc.typeArticleen_US

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