A systematic review of safety and adverse effects in the practice of therapeutic hypothermia

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dc.contributor.authorKarcıoğlu, Özgür
dc.contributor.authorTopaçoğlu, Hakan
dc.contributor.authorDikme, Özlem
dc.contributor.authorDikme, Özgür
dc.date.accessioned2020-04-30T22:38:54Z
dc.date.available2020-04-30T22:38:54Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionDikme, Ozgur/0000-0001-6221-7932; Dikme, Ozlem/0000-0002-9739-3925en_US
dc.descriptionWOS: 000445001600031en_US
dc.descriptionPubMed: 30017685en_US
dc.description.abstractObjective: To carry out a systematic review to estimate the rate and magnitude of adverse effects following therapeutic hypothermia (TH) procedure in patients resuscitated from out-of-hospital cardiac arrest (OHCA) and highlight the specific complications seen after the procedure. Methods: A systematic review of currently published studies was performed following standard guidelines. Online database searches were performed for controlled trials for the last twenty years. Papers were examined for methodological soundness before being included. Data were independently extracted by two blinded reviewers. Studies were also assessed for bias using the Cochrane criteria. The adverse effects attributed to TH in the literature were appraised critically. Results: The initial data search yielded 78 potentially relevant studies; of these, 59 were excluded for some reason. Themain reason for exclusion (n= 43, 55.8%) was that irrelevance to adverse effects of TH. Finally, 19 underwent full-text review. Studies were of high-to-moderate (n= 12, 63%) to low-to-very low (n= 7, 37%) quality. Five studies (27.7%) were found to have high risk of bias, while 8 (42.1%) had low risk of bias. Interpretation: Although adverse effects related to the practice of TH have been studied extensively, there is substantial heterogeneity between study populations and methodologies. There is a considerable incidence of side effects attributed to the procedure, e.g., from life-threatening ventricular arrhythmias to self-limited consequences. Most studies analyzed in this systematic review indicated that the procedure of TH has not caused severe adverse effects leading to significant alterations in the outcomes following resuscitation from OHCA. (C) 2018 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.ajem.2018.07.024en_US
dc.identifier.endpage1894en_US
dc.identifier.issn0735-6757
dc.identifier.issn1532-8171
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1886en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajem.2018.07.024
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2511
dc.identifier.volume36en_US
dc.identifier.wosWOS:000445001600031en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofAmerican Journal Of Emergency Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiac arresten_US
dc.subjectTherapeutic hypothermiaen_US
dc.subjectHypothermiaen_US
dc.subjectAdverse effectsen_US
dc.subjectSide effectsen_US
dc.subjectTargeted temperature managementen_US
dc.subjectOut-of-hospital cardiac arresten_US
dc.subjectSystematic reviewen_US
dc.titleA systematic review of safety and adverse effects in the practice of therapeutic hypothermiaen_US
dc.typeReview Articleen_US

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