A systematic review of safety and adverse effects in the practice of therapeutic hypothermia
Yükleniyor...
Dosyalar
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
W B Saunders Co-Elsevier Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To carry out a systematic review to estimate the rate and magnitude of adverse effects following therapeutic hypothermia (TH) procedure in patients resuscitated from out-of-hospital cardiac arrest (OHCA) and highlight the specific complications seen after the procedure. Methods: A systematic review of currently published studies was performed following standard guidelines. Online database searches were performed for controlled trials for the last twenty years. Papers were examined for methodological soundness before being included. Data were independently extracted by two blinded reviewers. Studies were also assessed for bias using the Cochrane criteria. The adverse effects attributed to TH in the literature were appraised critically. Results: The initial data search yielded 78 potentially relevant studies; of these, 59 were excluded for some reason. Themain reason for exclusion (n= 43, 55.8%) was that irrelevance to adverse effects of TH. Finally, 19 underwent full-text review. Studies were of high-to-moderate (n= 12, 63%) to low-to-very low (n= 7, 37%) quality. Five studies (27.7%) were found to have high risk of bias, while 8 (42.1%) had low risk of bias. Interpretation: Although adverse effects related to the practice of TH have been studied extensively, there is substantial heterogeneity between study populations and methodologies. There is a considerable incidence of side effects attributed to the procedure, e.g., from life-threatening ventricular arrhythmias to self-limited consequences. Most studies analyzed in this systematic review indicated that the procedure of TH has not caused severe adverse effects leading to significant alterations in the outcomes following resuscitation from OHCA. (C) 2018 Elsevier Inc. All rights reserved.
Açıklama
Dikme, Ozgur/0000-0001-6221-7932; Dikme, Ozlem/0000-0002-9739-3925
WOS: 000445001600031
PubMed: 30017685
WOS: 000445001600031
PubMed: 30017685
Anahtar Kelimeler
Cardiac arrest, Therapeutic hypothermia, Hypothermia, Adverse effects, Side effects, Targeted temperature management, Out-of-hospital cardiac arrest, Systematic review
Kaynak
American Journal Of Emergency Medicine
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
36
Sayı
10
