Effects of long-term exposure to 900 megahertz electromagnetic field on heart morphology and biochemistry of male adolescent rats

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dc.contributor.authorKerimoğlu, Gökçen
dc.contributor.authorMercantepe, Tolga
dc.contributor.authorErol, Hüseyin Serkan
dc.contributor.authorTurgut, Alpgiray
dc.contributor.authorKaya, Haydar
dc.contributor.authorÇolakoğlu, Serdar
dc.contributor.authorOdacı, Ersan
dc.date.accessioned2020-05-01T09:11:59Z
dc.date.available2020-05-01T09:11:59Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionMercantepe, Tolga/0000-0002-8506-1755; Erol, Huseyin Serkan/0000-0002-9121-536X; Kerimoglu, Gokcen/0000-0002-4349-7796en_US
dc.descriptionWOS: 000386589600001en_US
dc.descriptionPubMed: 27715326en_US
dc.description.abstractThe pathological effects of exposure to an electromagnetic field (EMF) during adolescence may be greater than those in adulthood. We investigated the effects of exposure to 900 MHz EMF during adolescence on male adult rats. Twenty-four 21-day-old male rats were divided into three equal groups: control (Cont-Gr), sham (Shm-Gr) and EMF-exposed (EMF-Gr). EMF-Gr rats were placed in an EMF exposure cage (Plexiglas cage) for 1 h/day between postnatal days 21 and 59 and exposed to 900 MHz EMF. Shm-Gr rats were placed inside the Plexiglas cage under the same conditions and for the same duration, but were not exposed to EMF. All animals were sacrificed on postnatal day 60 and the hearts were extracted for microscopic and biochemical analyses. Biochemical analysis showed increased levels of malondialdehyde and superoxide dismutase, and reduced glutathione and catalase levels in EMF-Gr compared to Cont-Gr animals. Hematoxylin and eosin stained sections from EMF-Gr animals exhibited structural changes and capillary congestion in the myocardium. The percentage of apoptotic myocardial cells in EMF-Gr was higher than in either Shm-Gr or Cont-Gr animals. Transmission electron microscopy of myocardial cells of EMF-Gr animals showed altered structure of Z bands, decreased myofilaments and pronounced vacuolization. We found that exposure of male rats to 900 MHz EMF for 1 h/day during adolescence caused oxidative stress, which caused structural alteration of male adolescent rat heart tissue.en_US
dc.description.sponsorshipKaradeniz Technical University Research Fund [12222]en_US
dc.description.sponsorshipOur work was supported by the Karadeniz Technical University Research Fund, Project number: 12222.en_US
dc.identifier.doi10.1080/10520295.2016.1216165en_US
dc.identifier.endpage454en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage445en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2016.1216165
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5839
dc.identifier.volume91en_US
dc.identifier.wosWOS:000386589600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadolescenten_US
dc.subjectapoptosisen_US
dc.subjectcellular phoneen_US
dc.subjectelectromagnetic fielden_US
dc.subjectelectron microcopyen_US
dc.subjecthearten_US
dc.subjectraten_US
dc.titleEffects of long-term exposure to 900 megahertz electromagnetic field on heart morphology and biochemistry of male adolescent ratsen_US
dc.typeArticleen_US

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