Effects of Hormone Replacement Therapy on Plasma and Tissue Fibrinolytic Activity in a Rat Model of Surgically Induced Menopause

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dc.contributor.authorTopçuoğlu, Ata
dc.contributor.authorAlbayrak, Mustafa
dc.contributor.authorErman, Hayriye
dc.contributor.authorBalcı, Huriye
dc.contributor.authorKarakuş, Mesut
dc.contributor.authorÇoban, İlker
dc.contributor.authorUzun, Hafize
dc.date.accessioned2020-05-01T09:11:58Z
dc.date.available2020-05-01T09:11:58Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionUzun, Hafize/0000-0002-1347-8498en_US
dc.descriptionWOS: 000334296500005en_US
dc.descriptionPubMed: 24690423en_US
dc.description.abstractPurpose: The purpose of this study was to analyze the effects of estrogen deficiency and hormone replacement therapy (HRT) on fibrinolytic activity in a rat mode of surgically induced menopause. Methods: Twelve-week-old, sexually mature female Sprague-Dawley rats, each weighing 200-250 g, were randomly divided into four groups: (1) sham- operated group, (2) ovariectomy group, (3) ovariectomy group followed by oral administration of daily 17 beta-estradiol (0.02 mg/kg/day) (E2) + norethisterone acetate (0.01 mg/kg/day), and (4) ovariectomy group followed by oral administration of daily 17 beta-estradiol (0.01 mg/kg/day) + drospirenone (0.02 mg/kg/day). Tissue plasminogen activator (tPA) antigen, plasminogen activator inhibitor-1 (PAI- 1) antigen, and PAI-1/tPA levels were measured as markers of fibrinolysis in plasma and liver and brain tissue. Results: Compared with sham-operated rats, ovariectomized rats showed higher levels of fibrinolytic activity; however, the increased fibrinolytic activity in plasma and liver tissue was significantly reduced by HRT regimens. No change was observed in the levels of fi brinolytic activity in brain tissue. Conclusions: HRT showed beneficial effects by decreasing fibrinolytic activity related to surgically induced menopause. Short-term HRT treatment was associated with a shift in the procoagulant-anticoagulant balance toward a procoagulant state.en_US
dc.identifier.endpageE92en_US
dc.identifier.issn0147-958X
dc.identifier.issn1488-2353
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpageE85en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5833
dc.identifier.volume37en_US
dc.identifier.wosWOS:000334296500005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCanadian Soc Clinical Investigationen_US
dc.relation.ispartofClinical And Investigative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEffects of Hormone Replacement Therapy on Plasma and Tissue Fibrinolytic Activity in a Rat Model of Surgically Induced Menopauseen_US
dc.typeArticleen_US

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