Protective effect of glucagon-like peptide-2 in experimental corrosive esophagitis

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dc.contributor.authorTekin, Mustafa
dc.contributor.authorTopaloğlu, Naci
dc.contributor.authorKüçük, Adem
dc.contributor.authorDeniz, Mustafa
dc.contributor.authorYıldırım, Şule
dc.contributor.authorErdem, Havva
dc.date.accessioned2020-04-30T23:21:51Z
dc.date.available2020-04-30T23:21:51Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionYildirim, Sule/0000-0002-1815-808Xen_US
dc.descriptionWOS: 000352501600010en_US
dc.descriptionPubMed: 24641662en_US
dc.description.abstractCorrosive esophageal injuries are one of the life-threatening morbidities leading to esophageal stricture and perforation affecting all age groups but especially children due to accidental ingestions in this age group. Glucagon-like peptide-2 (GLP-2) is an intestinal polypeptide with potent anti-inflammatory effects. Its effects are studied in various studies but not in corrosive esophagitis. We aimed to investigate whether it has protective effect in experimental corrosive esophagitis, in the absence of existing studies into possible links. Twenty-four Wistar-albino rats, weighing 220-240 g, were randomized into three groups (n=8 in each). First group is control, second one is sham operated, and the third one is treatment group. Median laparotomy was made in all groups. In sham and treatment groups, esophagus was loosened and suspended from 1cm proximal to the esophageal junction. The esophagus segment between suspenders was exposed to 0.1mL 5% NaOH for 10 seconds. In the treatment group, rats were given GLP-2 for 7 days intraperitoneally. After 7 days, all rats were sacrified and esophagi were totally removed. In the histopathologic examination, esophageal tissues were compared in terms of inflammation, muscularis mucosa injury, and collagen deposition of tunica muscularis. Histopathologic changes in the esophageal tissues of groups were compared. Histopathologic injury in the GLP-2 treated group was significantly less than sham group (P<0.05). There was statistically significant healing in the GLP-2 treatment group. It is concluded that GLP-2 has a preventive effect on inflammation and collagen accumulation in an experimental corrosive esophagitis. In the light of the information that initial lesions in the early phase are predictors of complications, GLP-2 is a promising agent that has an anti-inflammatory effect in caustic injuries.en_US
dc.identifier.doi10.1111/dote.12195en_US
dc.identifier.endpage261en_US
dc.identifier.issn1120-8694
dc.identifier.issn1442-2050
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage258en_US
dc.identifier.urihttps://doi.org/10.1111/dote.12195
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4259
dc.identifier.volume28en_US
dc.identifier.wosWOS:000352501600010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOxford Univ Press Incen_US
dc.relation.ispartofDiseases Of The Esophagusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcorrosive esophagitisen_US
dc.subjectglucagon-like peptide-2en_US
dc.subjectinflammationen_US
dc.subjectraten_US
dc.titleProtective effect of glucagon-like peptide-2 in experimental corrosive esophagitisen_US
dc.typeArticleen_US

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