Age-related changes in the rat hippocampus

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dc.contributor.authorİş, Merih
dc.contributor.authorÇomunoğlu, Nil
dc.contributor.authorÇomunoğlu, Cem
dc.contributor.authorEren, Bülent
dc.contributor.authorEkici, Işın Doğan
dc.contributor.authorÖzkan, Ferda
dc.date.accessioned2020-04-30T22:39:02Z
dc.date.available2020-04-30T22:39:02Z
dc.date.issued2008
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionDogan Ekici, Asiye Isin/0000-0003-4062-9519; Ozkan, Ferda/0000-0002-9919-0582en_US
dc.descriptionWOS: 000255339000014en_US
dc.descriptionPubMed: 18342510en_US
dc.description.abstractThe human brain is uniquely powerful in its cognitive abilities, yet the hippocampal and neocortical circuits that mediate these complex functions are highly vulnerable during aging. In this study, we analyzed age-related changes in the rat hippocampus by studying newborn (1 month), middle-aged (12 months), and older (24 months) male and female Sprague-Dawley rats. We evaluated neuronal dystrophy, neuron scattering, and granulovacuolar degeneration in the hippocampal area using light microscopy, according to age and gender. We detected significant neuronal dystrophy in the CA1, CA2, and CA3 areas in male rats, and in the CA1, CA3, and CA4 areas in female rats. Degenerative changes, indicated by neuron scattering, were observed in the CA1, CA2, and CA3 areas of male and the CA2 and CA4 areas of female rats. Changes in all areas of the hippocampus were observed with increasing age; these changes included neuronal dystrophy and neuron scattering and did not differ significantly between male and female rats. (C) 2007 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jocn.2007.03.025en_US
dc.identifier.endpage574en_US
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage568en_US
dc.identifier.urihttps://doi.org/10.1016/j.jocn.2007.03.025
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2573
dc.identifier.volume15en_US
dc.identifier.wosWOS:000255339000014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofJournal Of Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectagingen_US
dc.subjectgranulovacuolar degenerationen_US
dc.subjecthippocampusen_US
dc.subjectneuronal dystrophyen_US
dc.subjectneuron scatteringen_US
dc.titleAge-related changes in the rat hippocampusen_US
dc.typeArticleen_US

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