Synthesis of New 3,5-disubstituted-1,2,4-Triazoles and Evaluation of Antibacterial, Antiurease and Antioxidant Activities

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dc.contributor.authorGümrükçüoğlu, Nurhan
dc.contributor.authorSökmen, Bahar Bilgin
dc.contributor.authorŞahin, Hüseyin
dc.contributor.authorUğraş, Serpil
dc.contributor.authorSağkal, Yasemin
dc.contributor.authorUğraş, Halil İbrahim
dc.date.accessioned2020-04-30T23:32:27Z
dc.date.available2020-04-30T23:32:27Z
dc.date.issued2016
dc.departmentDÜ, Ziraat Fakültesi, Tarla Bitkileri Bölümüen_US
dc.descriptionSahin, Huseyin/0000-0002-6018-1494en_US
dc.descriptionWOS: 000390364000016en_US
dc.description.abstractAcylhydrazone 2 was synthesized by the condensation of iminoester hydrochloride 1 with acyl hydrazine. The treatment of acylhydrazone with hydrazine hydrate afforded 4-amino-3,5-dialkyl-1,2,4-triazole 3. The treatment of compound 3 with various aromatic aldehydes resulted in the formation of 4-arylidenamino-3, 5-dialkyl-1,2,4-triazoles 4a-c. Sodium borohydride reduction of 4-arylidenamino derivatives afforded 4-alkylamino-3,5-dialkyl- 1,2,4-triazoles 5a-c. The obtained products were identified by FTIR, H-1-NMR, C-13-NMR, Mass spectroscopic and elemental analysis. A series of compounds were evaluated for their, antibacterial, antiurease, antioxidant activities. The results showed that the synthesized new compounds had effective antibacterial, antioxidant, antiurease activities.en_US
dc.identifier.endpage936en_US
dc.identifier.issn0253-5106
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage928en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4725
dc.identifier.volume38en_US
dc.identifier.wosWOS:000390364000016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherChem Soc Pakistanen_US
dc.relation.ispartofJournal Of The Chemical Society Of Pakistanen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject1,2,4-triazoleen_US
dc.subjectSchiff baseen_US
dc.subjectReductionen_US
dc.subjectUrease inhibition activityen_US
dc.subjectAntioxidant activityen_US
dc.titleSynthesis of New 3,5-disubstituted-1,2,4-Triazoles and Evaluation of Antibacterial, Antiurease and Antioxidant Activitiesen_US
dc.typeArticleen_US

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